In this thesis, fluidized bed melt granulation of two pharmaceutical excipients is scrutinized from a micro scale level of scrutiny. Batch granulation tests were performed by previous research in process geometry of fluidized bed in a lab-scale. Binder, polyethylene glycol powder that provides necessary liquid bridges by melting, is used in physical conversion of a substance. The micro scale study of granulation phenomenon is focused towards detection of parameters of powder-binder interface for systems microcrystalline cellulose/polyethylene glycol and lactose monohydrate/polyethylene glycol. Experimental technique for measurement of contact angle using goniometer is used for characterization of two interfaces of interest. Contact angles of three test liquids with well known surface energies were determined on substrates of microcrystalline cellulose, lactose monohydrate and polyethylene glycol. Two parametric models were used for quantitative prediction of interactions. Surface free energies for each phase, interfacial energies of interest and corresponding values of thermodynamic work of adhesion and spreading coefficient were estimated using Owens-Wendt and Wu model. Adhesion parameters indicate weak interactions between microcrystalline cellulose and polyethylene glycol with possibility of phase dewetting and consequently on the inability for granulation of this system. Additionally, interface parameters indicate the possibility for establishment of considerable interactions between lactose monohydrate and polyethylene glycol.