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master's thesis
Viskoelastična svojstva PCL/fibroin/CFU elektroispredenih nosača
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:798561
Pašalić, Marta
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Pašalić, M. (2019). Viskoelastična svojstva PCL/fibroin/CFU elektroispredenih nosača (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:798561

Pašalić, Marta. "Viskoelastična svojstva PCL/fibroin/CFU elektroispredenih nosača." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:798561

Pašalić, Marta. "Viskoelastična svojstva PCL/fibroin/CFU elektroispredenih nosača." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:798561

Pašalić, M. (2019). 'Viskoelastična svojstva PCL/fibroin/CFU elektroispredenih nosača', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 March 2025, https://urn.nsk.hr/urn:nbn:hr:149:798561

Pašalić M. Viskoelastična svojstva PCL/fibroin/CFU elektroispredenih nosača [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2025 March 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:798561

M. Pašalić, "Viskoelastična svojstva PCL/fibroin/CFU elektroispredenih nosača", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:798561

Metadata
TitleViskoelastična svojstva PCL/fibroin/CFU elektroispredenih nosača
Title (english)Viscoelastic properties of PCL/fibroin/CFU elektrospinning scaffolds
AuthorMarta Pašalić
MentorEmi Govorčin Bajsić (mentor)
Committee memberEmi Govorčin Bajsić (predsjednik povjerenstva)
Committee memberZlata Hrnjak-Murgić (član povjerenstva)
Committee memberNevenka Vrbos (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Cilj ovog rada bio je istražiti utjecaj fibroina svile (FS) i različitog udjela antibiotika Cefuroxima (CFU) na viskoelastična, mehanička i toplinska svojstva PCL/FS/CFU elektroispredenih nosača u cilju sprječavanja infekcija oka nakon kirurškog zahvata. Postupkom elektroispredanja pripremili su se 18% PCL/10% FS vlaknasti nosači u koje je dodan CFU u koncentracijama od 4, 8 i 12%. Nakon postupka elektroispredanja uslijedila je karakterizacija materijala. Struktura elektroispredenih nosača... More određena je FTIR-ATR spektroskopijom, mehanička svojstva rasteznim ispitivanjem na mehaničkoj kidalici, toplinska svojstva termogravimetrijskom analizom te viskoelastična svojstva dinamičko-mehaničkom analizom. Dodatkom FS i CFU te povećanjem udjela CFU dolazi do smanjenja visine pika u području staklastog prijelaza u odnosu na elektroispredeni PCL nosač, ali visina maksimuma raste povećanjem udjela CFU. Na osnovi porasta Tg-a može se zaključiti da se kristalne domene FS smještaju u amorfnu fazu elektroispredenog PCL nosača i dolazi do interakcije između PCL-a i β-pločastih kristala iz FS čime se smanjuje pokretljivost amorfnih segmenata u PCL nosaču. Dodatkom FS u 18% PCL elektroispredeni nosač dolazi do povećanja prekidne čvrstoće i smanjenja prekidnog istezanja. Povećanjem udjela CFU-a u PCL/CFU/FS elektroispredene nosače dolazi do smanjenja prekidne čvrstoće i pada prekidnog istezanja. Na FTIR spektrima PCL/FS/CFU elektroispredenih nosača mogu se vidjeti tri karakteristične vrpce koje se pripisuju CFU. Toplinska stabilnost se smanjuje dodatkom 10% FS-a u 18% PCL elektroispredeni nosač kao i elektroispredenim PCL/FS/CFU nosačima dodatkom FS i CFU i povećanjem udjela CFU. Less
Abstract (english)
The aim of this work was to investigate the influence of silk fibroin (SF) and different content of antibiotic Cefuroxim (CFU) on the viscoelastic, mechanical and thermal properties of PCL/FS/CFU electrospun carriers in order to prevent eye infections after surgery. Electrospun 18% PCL and 10% FS fiber scaffolds are prepared by electrospinning with the addition of the CFU of 4,8 and 12 wt%. The electrospinning process was followed by characterization of the electrospun scaffolds. The... More structure of electrospun scaffolds was determined by FTIR-ATR spectroscopy, mechanical properties by tensile testing, thermal properties by thermogravimetric analysis and viscoelastic properties by dynamic-mechanical analysis. With the addition of FS and CFU and the increase of the CFU content, the peak in the glass transition region is reduced relative to the electrospun PCL carrier, but the peak maximum increases with the increase in the CFU content. Based on the increase in Tg, it can be concluded that the FS crystal domains are located in the amorphous phase of the electrospun PCL carrier and an interaction occurs between the PCL and β-plate crystals from FS, thus reducing the mobility of the amorphous segments in the PCL carrier. The addition of FS in an 18% PCL electrospun carriers results in an increase in tensile strength and a decrease elongation at break. Increasing the content of CFUs in PCL/CFU/FS electrospun carriers results in a decrease in tensile strength and elongation at break. On the FTIR spectra of PCL/FS/CFU electrospun carriers, three characteristic bands attributed to the CFU can be seen. Thermal stability is reduced by the addition of 10% FS in 18% PCL electrospun carrier as well as electrospun PCL/FS/CFU carriers by the addition of FS and CFU. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:798561
ProjectNumber: IP-2016-06-6878
Title: Ciljana izrada prototipa vlaknastog nosača za uzgoj tkivnih stanica kombiniranim elektroispredanjem
Acronym: COMBOELECTROSPUN
Leader: Budimir Mijović
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Materials Science and Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-02-26 13:06:11
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