prikaz prve stranice dokumenta Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis
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Scientific paper - Original scientific paper
Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis
International Journal of Molecular Sciences, 20 (2019), 21; 1-15. https://doi.org/10.3390/ijms20215461
Mihalj, Martina; Bujak, Maro; Butković, Josip; Zubčić, Željko; Tolušić Levak, Maja; Čes, Josip; Kopić, Vlatko; Baus Lončar, Mirela; Mihalj, Hrvoje

Institutional repository: Repository UHC Osijek

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Mihalj, M., Bujak, M., Butković, J., Zubčić, Ž., Tolušić Levak, M., Čes, J. ... Mihalj, H. (2019). Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis. International Journal of Molecular Sciences, 20. (21), 1-15. doi: 10.3390/ijms20215461

Mihalj, Martina, et al. "Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis." International Journal of Molecular Sciences, vol. 20, no. 21, 2019, pp. 1-15. https://doi.org/10.3390/ijms20215461

Mihalj, Martina, Maro Bujak, Josip Butković, Željko Zubčić, Maja Tolušić Levak, Josip Čes, Vlatko Kopić, Mirela Baus Lončar and Hrvoje Mihalj. "Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis." International Journal of Molecular Sciences 20, no. 21 (2019): 1-15. https://doi.org/10.3390/ijms20215461

Mihalj, M., et al. (2019) 'Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis', International Journal of Molecular Sciences, 20(21), pp. 1-15. doi: 10.3390/ijms20215461

Mihalj M, Bujak M, Butković J, Zubčić Ž, Tolušić Levak M, Čes J, and sur.. Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis. International Journal of Molecular Sciences [Internet]. 2019 [cited 2024 May 21];20(21):1-15. doi: 10.3390/ijms20215461

M. Mihalj, et al., "Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis", International Journal of Molecular Sciences, vol. 20, no. 21, pp. 1-15, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:843601. [Accessed: 21 May 2024]

Metadata
Title (english)Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis
AuthorMartina Mihalj
MBZ: 322792
AuthorMaro Bujak
MBZ: 305001
AuthorJosip Butković
MBZ: 109163
AuthorŽeljko Zubčić
MBZ: 345090
AuthorMaja Tolušić Levak
MBZ: 338680
AuthorJosip Čes
AuthorVlatko Kopić
MBZ: 379790
AuthorMirela Baus Lončar
MBZ: 222563
AuthorHrvoje Mihalj
MBZ: 347871
Author's institutionRuđer Bošković Institute
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
(Department of Infectious Diseases and Dermatovenereology)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
(Department of Otorhinolaryngology and Maxillofacial Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Trefoil family factor (TFF) proteins contribute to antimicrobial defense and the maintenance of sinonasal epithelial barrier integrity. Dysregulation of TFF expression may be involved in the development of chronic inflammation and tissue remodeling characteristically found in chronic rhinosinusitis with nasal polyposis (CRSwNP). Expressions of TFF1 and TFF3 were determined in specimens of middle nasal turbinate (MNT-0), bulla ethmoidalis (BE), and nasal polyps (NP) from CRSwNP patients (n = 29) and inferior nasal turbinate from a group of control patients (underwent nasal septoplasty, n = 25). An additional MNT sample was collected 6 months after functional endoscopic sinus surgery (FESS, MNT-6). TFF1 mRNA levels were significantly reduced in all specimens by approximately three- to five-fold, while TFF3 was increased in MNT-0, as compared with controls. Six months after surgery their levels were reversed to control values. CRSwNP patients with S. epidermidis isolated from sinus swabs showed upregulation of TFF3 in MNT and NP as compared with patients with sterile swabs. Target gene regulation was not affected by the presence of type 2 inflammation in patients with confirmed allergy. Results of this study imply participation of TFFs genes in the development of CRSwNP.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 20, no. 21, pp. 1-15
p-ISSN1661-6596
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms20215461
URN:NBNurn:nbn:hr:239:843601
Publication2019
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862153/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-01-17 12:01:54