prikaz prve stranice dokumenta Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis
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Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis
International Journal of Molecular Sciences, 20 (2019), 21; 1-15. https://doi.org/10.3390/ijms20215461
Mihalj, Martina; Bujak, Maro; Butković, Josip; Zubčić, Željko; Tolušić Levak, Maja; Čes, Josip; Kopić, Vlatko; Baus Lončar, Mirela; Mihalj, Hrvoje

Institucijski repozitorij: Repozitorij KBC Osijek

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Mihalj, M., Bujak, M., Butković, J., Zubčić, Ž., Tolušić Levak, M., Čes, J. ... Mihalj, H. (2019). Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis. International Journal of Molecular Sciences, 20. (21), 1-15. doi: 10.3390/ijms20215461

Mihalj, Martina, et al. "Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis." International Journal of Molecular Sciences, vol. 20, br. 21, 2019, str. 1-15. https://doi.org/10.3390/ijms20215461

Mihalj, Martina, Maro Bujak, Josip Butković, Željko Zubčić, Maja Tolušić Levak, Josip Čes, Vlatko Kopić, Mirela Baus Lončar i Hrvoje Mihalj. "Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis." International Journal of Molecular Sciences 20, br. 21 (2019): 1-15. https://doi.org/10.3390/ijms20215461

Mihalj, M., et al. (2019) 'Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis', International Journal of Molecular Sciences, 20(21), str. 1-15. doi: 10.3390/ijms20215461

Mihalj M, Bujak M, Butković J, Zubčić Ž, Tolušić Levak M, Čes J, i sur.. Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis. International Journal of Molecular Sciences [Internet]. 2019. [pristupljeno 16.05.2024.];20(21):1-15. doi: 10.3390/ijms20215461

M. Mihalj, et al., "Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis", International Journal of Molecular Sciences, vol. 20, br. 21, str. 1-15, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:843601. [Citirano: 16.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:239:843601
Podaci o radu
Naslov (engleski)Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis
AutorMartina Mihalj
MBZ: 322792
AutorMaro Bujak
MBZ: 305001
AutorJosip Butković
MBZ: 109163
AutorŽeljko Zubčić
MBZ: 345090
AutorMaja Tolušić Levak
MBZ: 338680
AutorJosip Čes
AutorVlatko Kopić
MBZ: 379790
AutorMirela Baus Lončar
MBZ: 222563
AutorHrvoje Mihalj
MBZ: 347871
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
(Katedra za infektologiju i dermatovenerologiju)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
(Katedra za otorinolaringologiju i maksilofacijalnu kirurgiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Otorinolaringologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Trefoil family factor (TFF) proteins contribute to antimicrobial defense and the maintenance of sinonasal epithelial barrier integrity. Dysregulation of TFF expression may be involved in the development of chronic inflammation and tissue remodeling characteristically found in chronic rhinosinusitis with nasal polyposis (CRSwNP). Expressions of TFF1 and TFF3 were determined in specimens of middle nasal turbinate (MNT-0), bulla ethmoidalis (BE), and nasal polyps (NP) from CRSwNP patients (n = 29) and inferior nasal turbinate from a group of control patients (underwent nasal septoplasty, n = 25). An additional MNT sample was collected 6 months after functional endoscopic sinus surgery (FESS, MNT-6). TFF1 mRNA levels were significantly reduced in all specimens by approximately three- to five-fold, while TFF3 was increased in MNT-0, as compared with controls. Six months after surgery their levels were reversed to control values. CRSwNP patients with S. epidermidis isolated from sinus swabs showed upregulation of TFF3 in MNT and NP as compared with patients with sterile swabs. Target gene regulation was not affected by the presence of type 2 inflammation in patients with confirmed allergy. Results of this study imply participation of TFFs genes in the development of CRSwNP.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 20, br. 21, str. 1-15
p-ISSN1661-6596
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms20215461
URN:NBNurn:nbn:hr:239:843601
Datum objave publikacije2019
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862153/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-01-17 12:01:54