prikaz prve stranice dokumenta Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
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Scientific paper - Original scientific paper
Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
Biomolecules, 13 (2023), 5; 800. https://doi.org/10.3390/biom13050800
Konjevod, Marcela; Sreter, Katherina B.; Popovic-Grle, Sanja; Lampalo, Marina; Tudor, Lucija; Jukic, Irena; Nedic Erjavec, Gordana; Bingulac-Popovic, Jasna; Safic Stanic, Hana; Nikolac Perkovic, Matea; Markeljevic, Jasenka; Samarzija, Miroslav; Pivac, Nela; Svob Strac, Dubravka

Institutional repository: Repository of the Sestre milosrdnice University Hospital Center

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Konjevod, M., Sreter, K. B., Popovic Grle, S., Lampalo, M., Tudor, L., Jukic, I. ... Svob Strac, D. (2023). Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules, 13. (5). doi: 10.3390/biom13050800

Konjevod, Marcela, et al. "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma." Biomolecules, vol. 13, no. 5, 2023. https://doi.org/10.3390/biom13050800

Konjevod, Marcela, Katherina B. Sreter, Sanja Popovic Grle, Marina Lampalo, Lucija Tudor, Irena Jukic, Gordana Nedic Erjavec, et al. "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma." Biomolecules 13, no. 5 (2023). https://doi.org/10.3390/biom13050800

Konjevod, M., et al. (2023) 'Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma', Biomolecules, 13(5). doi: 10.3390/biom13050800

Konjevod M, Sreter KB, Popovic Grle S, Lampalo M, Tudor L, Jukic I, and sur.. Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules [Internet]. 2023 May 08 [cited 2024 November 06];13(5). doi: 10.3390/biom13050800

M. Konjevod, et al., "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma", Biomolecules, vol. 13, no. 5, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:597503. [Accessed: 06 November 2024]

Metadata
Title (english)Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
AuthorMarcela Konjevod
AuthorKatherina B. Sreter
AuthorSanja Popovic-Grle
AuthorMarina Lampalo
AuthorLucija Tudor
AuthorIrena Jukic
AuthorGordana Nedic Erjavec
AuthorJasna Bingulac-Popovic
AuthorHana Safic Stanic
AuthorMatea Nikolac Perkovic
AuthorJasenka Markeljevic
AuthorMiroslav Samarzija
AuthorNela Pivac
AuthorDubravka Svob Strac
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet serotonin (5-HT) levels and platelet monoamine oxidase B (MAO-B) activity, as well as associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), and MAOB (rs1799836; rs6651806) gene polymorphisms in 120 healthy individuals and 120 asthma patients of different severity and phenotypes. Platelet 5-HT concentration was significantly lower, while platelet MAO-B activity was considerably higher in asthma patients; however, they did not differ between patients with different asthma severity or phenotypes. Only the healthy subjects, but not the asthma patients, carrying the MAOB rs1799836 TT genotype had significantly lower platelet MAO-B activity than the C allele carriers. No significant differences in the frequency of the genotypes, alleles, or haplotypes for any of the investigated HTR2A, HTR2C and MAOB gene polymorphisms have been observed between asthma patients and healthy subjects or between patients with various asthma phenotypes. However, the carriers of the HTR2C rs518147 CC genotype or C allele were significantly less frequent in severe asthma patients than in the G allele carriers. Further studies are necessary to elucidate the involvement of the serotonergic system in asthma pathophysiology.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 13, no. 5, 800
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13050800
URN:NBNurn:nbn:hr:220:597503
Publication2023-05-08
Document URLhttps://www.mdpi.com/2218-273X/13/5/800
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-23 09:09:25