prikaz prve stranice dokumenta Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
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Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
Biomolecules, 13 (2023), 5; 800. https://doi.org/10.3390/biom13050800
Konjevod, Marcela; Sreter, Katherina B.; Popovic-Grle, Sanja; Lampalo, Marina; Tudor, Lucija; Jukic, Irena; Nedic Erjavec, Gordana; Bingulac-Popovic, Jasna; Safic Stanic, Hana; Nikolac Perkovic, Matea; Markeljevic, Jasenka; Samarzija, Miroslav; Pivac, Nela; Svob Strac, Dubravka

Institucijski repozitorij: Repozitorij Kliničkog bolničkog centra Sestre milosrdnice

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Konjevod, M., Sreter, K. B., Popovic Grle, S., Lampalo, M., Tudor, L., Jukic, I. ... Svob Strac, D. (2023). Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules, 13. (5). doi: 10.3390/biom13050800

Konjevod, Marcela, et al. "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma." Biomolecules, vol. 13, br. 5, 2023. https://doi.org/10.3390/biom13050800

Konjevod, Marcela, Katherina B. Sreter, Sanja Popovic Grle, Marina Lampalo, Lucija Tudor, Irena Jukic, Gordana Nedic Erjavec, et al. "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma." Biomolecules 13, br. 5 (2023). https://doi.org/10.3390/biom13050800

Konjevod, M., et al. (2023) 'Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma', Biomolecules, 13(5). doi: 10.3390/biom13050800

Konjevod M, Sreter KB, Popovic Grle S, Lampalo M, Tudor L, Jukic I, i sur.. Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules [Internet]. 08.05.2023. [pristupljeno 25.11.2024.];13(5). doi: 10.3390/biom13050800

M. Konjevod, et al., "Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma", Biomolecules, vol. 13, br. 5, Svibanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:597503. [Citirano: 25.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:220:597503
Podaci o radu
Naslov (engleski)Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma
AutorMarcela Konjevod
AutorKatherina B. Sreter
AutorSanja Popovic-Grle
AutorMarina Lampalo
AutorLucija Tudor
AutorIrena Jukic
AutorGordana Nedic Erjavec
AutorJasna Bingulac-Popovic
AutorHana Safic Stanic
AutorMatea Nikolac Perkovic
AutorJasenka Markeljevic
AutorMiroslav Samarzija
AutorNela Pivac
AutorDubravka Svob Strac
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet serotonin (5-HT) levels and platelet monoamine oxidase B (MAO-B) activity, as well as associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), and MAOB (rs1799836; rs6651806) gene polymorphisms in 120 healthy individuals and 120 asthma patients of different severity and phenotypes. Platelet 5-HT concentration was significantly lower, while platelet MAO-B activity was considerably higher in asthma patients; however, they did not differ between patients with different asthma severity or phenotypes. Only the healthy subjects, but not the asthma patients, carrying the MAOB rs1799836 TT genotype had significantly lower platelet MAO-B activity than the C allele carriers. No significant differences in the frequency of the genotypes, alleles, or haplotypes for any of the investigated HTR2A, HTR2C and MAOB gene polymorphisms have been observed between asthma patients and healthy subjects or between patients with various asthma phenotypes. However, the carriers of the HTR2C rs518147 CC genotype or C allele were significantly less frequent in severe asthma patients than in the G allele carriers. Further studies are necessary to elucidate the involvement of the serotonergic system in asthma pathophysiology.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 13, br. 5, 800
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13050800
URN:NBNurn:nbn:hr:220:597503
Datum objave publikacije2023-05-08
URL dokumentahttps://www.mdpi.com/2218-273X/13/5/800
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-09-23 09:09:25