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undergraduate thesis
Kompleksi prijelaznih metala i kojinske kiseline: priprava i biološka aktivnost
Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. urn:nbn:hr:182:463340
Janković, Jelena
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of General, Inorganic and Physical Chemistry and Methodology of Chemistry

Institutional repository: Repository of the Department of Chemistry, Osijek

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Janković, J. (2024). Kompleksi prijelaznih metala i kojinske kiseline: priprava i biološka aktivnost (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:463340

Janković, Jelena. "Kompleksi prijelaznih metala i kojinske kiseline: priprava i biološka aktivnost." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:182:463340

Janković, Jelena. "Kompleksi prijelaznih metala i kojinske kiseline: priprava i biološka aktivnost." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:182:463340

Janković, J. (2024). 'Kompleksi prijelaznih metala i kojinske kiseline: priprava i biološka aktivnost', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 05 September 2024, https://urn.nsk.hr/urn:nbn:hr:182:463340

Janković J. Kompleksi prijelaznih metala i kojinske kiseline: priprava i biološka aktivnost [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2024 [cited 2024 September 05] Available at: https://urn.nsk.hr/urn:nbn:hr:182:463340

J. Janković, "Kompleksi prijelaznih metala i kojinske kiseline: priprava i biološka aktivnost", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:182:463340

Metadata
TitleKompleksi prijelaznih metala i kojinske kiseline: priprava i biološka aktivnost
Title (english)Transition metals complexes of kojic acid: preparation and biological activity
AuthorJelena Janković
MentorMartina Šrajer Gajdošik (mentor)
Committee memberElvira Kovač-Andrić (predsjednik povjerenstva)
Committee memberMartina Šrajer Gajdošik (član povjerenstva)
Committee memberOlivera Galović (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of General, Inorganic and Physical Chemistry and Methodology of Chemistry)
Osijek
Defense date and country2024-07-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Inorganic Chemistry
Abstract
Kojinska kiselina (5-hidroksi-2-hidroksimetil-4-piron, C6H6O4) je organska kiselina koja je dobro topljiva u vodi, etanolu i acetonu. Jedan je od nusprodukata u procesu fermentacije riže za slad koji se koristi u proizvodnji sakea, japanskog rižinog vina. Inhibitor je rasta bakterija, gljivica te spriječava razmnožavanje virusa. Zbog mogućnosti modifikacije strukture, što za posljedicu ima brojne strukturne transformacije, danas je poznat velik broj derivata kojinske kiseline, kao i kompleksa prijelaznih metala u kojima se ona koristi kao ligand. Spomenute se skupine spojeva intenzivno proučavaju zbog svoje potencijalne biološke aktivnosti. U ovom radu predstavljeni su značajni rezultati iz literaturno dostupnih podataka koji pokazuju raznovrsnost priprave kompleksa kojinske kiseline, zastupljenost esencijalnih metalnih iona u takvim spojevima, kao i njihovu biološku evaluaciju. U prvom dijelu rada opisane su strukturne značajke kojinske kiseline, najčešće metode priprave kompleksa s kojinskom kiselinom i testovi citotoksičnosti, nakon čega slijedi pregled novijih rezultata vezanih uz protutumorsku, antibakterijsku i antifungalnu aktivnost kompleksa prijelaznih metala s kojinskom kiselinom.
Abstract (english)
Kojic acid (5-hydroxy-2-hydroxymethyl-4-pyrone, C6H6O4) is an organic acid that is highly soluble in water, ethanol and acetone. This acid is a by-product of the fermentation process of malted rice, which is used for the production of sake, a Japanese rice wine. It is an inhibitor for the growth of bacteria and fungi and prevents the multiplication of viruses. Today, a large number of kojic acid derivatives and transition metal complexes are known because they can change their structure, leading to structural transformations. These compounds are intensively studied due to their potential biological activity. In this paper, important results from the literature are presented, showing the diversity of preparation of kojic acid complexes, the presence of essential metal ions in such compounds and their biological evaluation. The first part of the article describes the structural characteristics of kojic acid, the most common methods for the preparation of complexes with kojic acid and cytotoxicity tests, followed by an overview of recent results on the antitumor, antibacterial and antifungal activity of complexes of transition metals with kojic acid.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:463340
Study programmeTitle: University Undergraduate Study program Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-07-19 07:19:12