prikaz prve stranice dokumenta The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients
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Scientific paper - Original scientific paper
The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients
Journal of neural transmission, 124 (2017), 4; 511-518. https://doi.org/10.1007/s00702-016-1670-y
Nadalin, Sergej; Ristić, Smiljana; Rebić, Jelena; Šendula Jengić, Vesna; Kapović, Miljenko; Buretić-Tomljanović, Alena

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Nadalin, S., Ristić, S., Rebić, J., Šendula Jengić, V., Kapović, M. & Buretić Tomljanović, A. (2017). The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients. Journal of neural transmission, 124. (4), 511-518. doi: 10.1007/s00702-016-1670-y

Nadalin, Sergej, et al. "The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients." Journal of neural transmission, vol. 124, no. 4, 2017, pp. 511-518. https://doi.org/10.1007/s00702-016-1670-y

Nadalin, Sergej, Smiljana Ristić, Jelena Rebić, Vesna Šendula Jengić, Miljenko Kapović and Alena Buretić Tomljanović. "The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients." Journal of neural transmission 124, no. 4 (2017): 511-518. https://doi.org/10.1007/s00702-016-1670-y

Nadalin, S., et al. (2017) 'The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients', Journal of neural transmission, 124(4), pp. 511-518. doi: 10.1007/s00702-016-1670-y

Nadalin S, Ristić S, Rebić J, Šendula Jengić V, Kapović M, Buretić Tomljanović A. The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients. Journal of neural transmission [Internet]. 2017 [cited 2024 April 19];124(4):511-518. doi: 10.1007/s00702-016-1670-y

S. Nadalin, S. Ristić, J. Rebić, V. Šendula Jengić, M. Kapović and A. Buretić Tomljanović, "The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients", Journal of neural transmission, vol. 124, no. 4, pp. 511-518, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:649491. [Accessed: 19 April 2024]

Metadata
Title (english)The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients
AuthorSergej Nadalin
AuthorSmiljana Ristić
AuthorJelena Rebić
AuthorVesna Šendula Jengić
AuthorMiljenko Kapović
AuthorAlena Buretić-Tomljanović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We investigated the relationship between the functional insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the risk of nicotine dependence in Croatian schizophrenia patients. We also tested whether interactions between ACE-I/D polymorphism and smoking status affected the clinical psychopathology findings in patients as measured using Positive and Negative Symptom Scale (PANSS) scores. Polymerase chain reaction analysis was used to genotype 267 chronically ill schizophrenia patients (140 males/127 females).There were no significant differences in the distribution of ACE genotypes and alleles in male or female schizophrenia patients who were stratified based on their smoking status. However, there was a trend toward a difference in the ACE genotype distribution in female smokers vs. nonsmokers (χ2 = 5.13, p = 0.077) that was due mainly to the significant overrepresentation of ACE-ID heterozygous genotypes in female smokers compared to nonsmokers (62.3% vs. 42.0%, p = 0.025). ACE-ID heterozygous females had about a 2-fold higher smoking risk than ACE-II and ACE-DD homozygous carriers (OR = 2.29, 95% CI = 1.1–4.7, p = 0.026). We observed no contribution of the ACE genotype-smoking interaction to PANSS psychopathology. This is the first study to investigate the possible association between ACE-I/D polymorphism and nicotine dependence in schizophrenia. Our results suggest that the ACE-I/D polymorphism may be relevant in determining the risk of nicotine dependence in female patients with schizophrenia while the ACE genotype-smoking interaction does not contribute to the clinical expression of schizophrenia. Izvorni jezik: ENG
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of neural transmission
Numberingvol. 124, no. 4, pp. 511-518
e-ISSN0300-9564
DOIhttps://doi.org/10.1007/s00702-016-1670-y
URN:NBNurn:nbn:hr:184:649491
Publication2017
Document URLhttps://link.springer.com/article/10.1007/s00702-016-1670-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-05-17 16:30:34