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The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients
Journal of neural transmission, 124 (2017), 4; 511-518. https://doi.org/10.1007/s00702-016-1670-y
Nadalin, Sergej; Ristić, Smiljana; Rebić, Jelena; Šendula Jengić, Vesna; Kapović, Miljenko; Buretić-Tomljanović, Alena

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Nadalin, S., Ristić, S., Rebić, J., Šendula Jengić, V., Kapović, M. i Buretić Tomljanović, A. (2017). The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients. Journal of neural transmission, 124. (4), 511-518. doi: 10.1007/s00702-016-1670-y

Nadalin, Sergej, et al. "The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients." Journal of neural transmission, vol. 124, br. 4, 2017, str. 511-518. https://doi.org/10.1007/s00702-016-1670-y

Nadalin, Sergej, Smiljana Ristić, Jelena Rebić, Vesna Šendula Jengić, Miljenko Kapović i Alena Buretić Tomljanović. "The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients." Journal of neural transmission 124, br. 4 (2017): 511-518. https://doi.org/10.1007/s00702-016-1670-y

Nadalin, S., et al. (2017) 'The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients', Journal of neural transmission, 124(4), str. 511-518. doi: 10.1007/s00702-016-1670-y

Nadalin S, Ristić S, Rebić J, Šendula Jengić V, Kapović M, Buretić Tomljanović A. The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients. Journal of neural transmission [Internet]. 2017. [pristupljeno 07.11.2024.];124(4):511-518. doi: 10.1007/s00702-016-1670-y

S. Nadalin, S. Ristić, J. Rebić, V. Šendula Jengić, M. Kapović i A. Buretić Tomljanović, "The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients", Journal of neural transmission, vol. 124, br. 4, str. 511-518, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:649491. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:649491
Podaci o radu
Naslov (engleski)The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients
AutorSergej Nadalin
AutorSmiljana Ristić
AutorJelena Rebić
AutorVesna Šendula Jengić
AutorMiljenko Kapović
AutorAlena Buretić-Tomljanović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We investigated the relationship between the functional insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the risk of nicotine dependence in Croatian schizophrenia patients. We also tested whether interactions between ACE-I/D polymorphism and smoking status affected the clinical psychopathology findings in patients as measured using Positive and Negative Symptom Scale (PANSS) scores. Polymerase chain reaction analysis was used to genotype 267 chronically ill schizophrenia patients (140 males/127 females).There were no significant differences in the distribution of ACE genotypes and alleles in male or female schizophrenia patients who were stratified based on their smoking status. However, there was a trend toward a difference in the ACE genotype distribution in female smokers vs. nonsmokers (χ2 = 5.13, p = 0.077) that was due mainly to the significant overrepresentation of ACE-ID heterozygous genotypes in female smokers compared to nonsmokers (62.3% vs. 42.0%, p = 0.025). ACE-ID heterozygous females had about a 2-fold higher smoking risk than ACE-II and ACE-DD homozygous carriers (OR = 2.29, 95% CI = 1.1–4.7, p = 0.026). We observed no contribution of the ACE genotype-smoking interaction to PANSS psychopathology. This is the first study to investigate the possible association between ACE-I/D polymorphism and nicotine dependence in schizophrenia. Our results suggest that the ACE-I/D polymorphism may be relevant in determining the risk of nicotine dependence in female patients with schizophrenia while the ACE genotype-smoking interaction does not contribute to the clinical expression of schizophrenia. Izvorni jezik: ENG
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of neural transmission
Brojčani podacivol. 124, br. 4, str. 511-518
e-ISSN0300-9564
DOIhttps://doi.org/10.1007/s00702-016-1670-y
URN:NBNurn:nbn:hr:184:649491
Datum objave publikacije2017
URL dokumentahttps://link.springer.com/article/10.1007/s00702-016-1670-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2017-05-17 16:30:34