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Scientific paper - Original scientific paper
A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients
Collegium antropologicum, 29 (2005), 2; 661-669. urn:nbn:hr:184:371763
Ravlić-Gulan, Jagoda; Gulan, Gordan; Novak, Srđan; Duletić-Načinović, Antica; Matovinović, Damir; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Ravlić Gulan, J., Gulan, G., Novak, S., Duletić Načinović, A., Matovinović, D. & Rukavina, D. (2005). A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients. Collegium antropologicum, 29. (2), 661-669. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:371763

Ravlić Gulan, Jagoda, et al. "A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients." Collegium antropologicum, vol. 29, no. 2, 2005, pp. 661-669. https://urn.nsk.hr/urn:nbn:hr:184:371763

Ravlić Gulan, Jagoda, Gordan Gulan, Srđan Novak, Antica Duletić Načinović, Damir Matovinović and Daniel Rukavina. "A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients." Collegium antropologicum 29, no. 2 (2005): 661-669. https://urn.nsk.hr/urn:nbn:hr:184:371763

Ravlić Gulan, J., et al. (2005) 'A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients', Collegium antropologicum, 29(2), pp. 661-669. Available at: https://urn.nsk.hr/urn:nbn:hr:184:371763 (Accessed 20 April 2024)

Ravlić Gulan J, Gulan G, Novak S, Duletić Načinović A, Matovinović D, Rukavina D. A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients. Collegium antropologicum [Internet]. 2005 December 15 [cited 2024 April 20];29(2):661-669. Available at: https://urn.nsk.hr/urn:nbn:hr:184:371763

J. Ravlić Gulan, G. Gulan, S. Novak, A. Duletić Načinović, D. Matovinović and D. Rukavina, "A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients", Collegium antropologicum, vol. 29, no. 2, pp. 661-669, December 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:371763. [Accessed: 20 April 2024]

Metadata
Title (english)A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients
AuthorJagoda Ravlić-Gulan
AuthorGordan Gulan
AuthorSrđan Novak
AuthorAntica Duletić-Načinović
AuthorDamir Matovinović
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Abstract (english)
Rheumatoid arthritis (RA) is one of the most destructive inflammatory and autoimmune joint diseases, most frequently accompanied by extraarticular complications. The pathophysiologic mechanism and the importance of cell subpopulations in the initiation and perpetuation of synovitis are not sufficiently understood. In this study the frequency of lymphocyte subpopulations simultaneously in the synovial fluid (SF), the synovial membrane (SM) and peripheral blood (PB) of acute RA patients is determined, using flow cytometry procedures. The changes in the distribution of T lymphocyte subpopulations were significant on local levels in acute RA patients, resulting in a decreased CD4/CD8 ratio in SF, but an increased CD4/CD8 ratio in SM, compared to the ratio found in PB. The differences observed in the frequency of cells positive on natural killer (NK) cell markers suggest the role of CD16-CD56+ NK cell population in SF of RA patients. Significant differences in the observed frequency of lymphatic subpopulations suggest certain specificities of local immunological events in SM and SF in acute RA. These results confirm the T-lymphocyte hypothesis in initial pathogenic events in RA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 29, no. 2, pp. 661-669
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:371763
Publication2005-12-15
Document URLhttp://hrcak.srce.hr/5315
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-08-03 07:02:45