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A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients
Collegium antropologicum, 29 (2005), 2; 661-669. urn:nbn:hr:184:371763
Ravlić-Gulan, Jagoda; Gulan, Gordan; Novak, Srđan; Duletić-Načinović, Antica; Matovinović, Damir; Rukavina, Daniel

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Ravlić Gulan, J., Gulan, G., Novak, S., Duletić Načinović, A., Matovinović, D. i Rukavina, D. (2005). A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients. Collegium antropologicum, 29. (2), 661-669. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:371763

Ravlić Gulan, Jagoda, et al. "A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients." Collegium antropologicum, vol. 29, br. 2, 2005, str. 661-669. https://urn.nsk.hr/urn:nbn:hr:184:371763

Ravlić Gulan, Jagoda, Gordan Gulan, Srđan Novak, Antica Duletić Načinović, Damir Matovinović i Daniel Rukavina. "A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients." Collegium antropologicum 29, br. 2 (2005): 661-669. https://urn.nsk.hr/urn:nbn:hr:184:371763

Ravlić Gulan, J., et al. (2005) 'A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients', Collegium antropologicum, 29(2), str. 661-669. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:371763 (Datum pristupa: 28.12.2024.)

Ravlić Gulan J, Gulan G, Novak S, Duletić Načinović A, Matovinović D, Rukavina D. A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients. Collegium antropologicum [Internet]. 15.12.2005. [pristupljeno 28.12.2024.];29(2):661-669. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:371763

J. Ravlić Gulan, G. Gulan, S. Novak, A. Duletić Načinović, D. Matovinović i D. Rukavina, "A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients", Collegium antropologicum, vol. 29, br. 2, str. 661-669, Prosinac 2005. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:371763. [Citirano: 28.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:371763
Podaci o radu
Naslov (engleski)A Comparison of Lymphocyte Subpopulations Simultaneously on Local and Systemic Levels in Acute Rheumatoid Arthritis Patients
AutorJagoda Ravlić-Gulan
AutorGordan Gulan
AutorSrđan Novak
AutorAntica Duletić-Načinović
AutorDamir Matovinović
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patofiziologija
Sažetak (engleski)
Rheumatoid arthritis (RA) is one of the most destructive inflammatory and autoimmune joint diseases, most frequently accompanied by extraarticular complications. The pathophysiologic mechanism and the importance of cell subpopulations in the initiation and perpetuation of synovitis are not sufficiently understood. In this study the frequency of lymphocyte subpopulations simultaneously in the synovial fluid (SF), the synovial membrane (SM) and peripheral blood (PB) of acute RA patients is determined, using flow cytometry procedures. The changes in the distribution of T lymphocyte subpopulations were significant on local levels in acute RA patients, resulting in a decreased CD4/CD8 ratio in SF, but an increased CD4/CD8 ratio in SM, compared to the ratio found in PB. The differences observed in the frequency of cells positive on natural killer (NK) cell markers suggest the role of CD16-CD56+ NK cell population in SF of RA patients. Significant differences in the observed frequency of lymphatic subpopulations suggest certain specificities of local immunological events in SM and SF in acute RA. These results confirm the T-lymphocyte hypothesis in initial pathogenic events in RA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 29, br. 2, str. 661-669
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:371763
Datum objave publikacije2005-12-15
URL dokumentahttp://hrcak.srce.hr/5315
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-08-03 07:02:45