prikaz prve stranice dokumenta Successful right atrial thrombus lysis with alteplase in a nine month old infant
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Successful right atrial thrombus lysis with alteplase in a nine month old infant
Signa vitae : journal for intesive care and emergency medicine, 8 (2013), 1; 59-61. urn:nbn:hr:184:820255
Lah Tomulić, Kristina; Frketa, Neven; Čače, Neven; Roganović, Jelena; Banac, Srđan; Tomulić, Vjekoslav; Gobić, David

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Lah Tomulić, K., Frketa, N., Čače, N., Roganović, J., Banac, S., Tomulić, V. & Gobić, D. (2013). Successful right atrial thrombus lysis with alteplase in a nine month old infant. Signa vitae : journal for intesive care and emergency medicine, 8. (1), 59-61. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:820255

Lah Tomulić, Kristina, et al. "Successful right atrial thrombus lysis with alteplase in a nine month old infant." Signa vitae : journal for intesive care and emergency medicine, vol. 8, no. 1, 2013, pp. 59-61. https://urn.nsk.hr/urn:nbn:hr:184:820255

Lah Tomulić, Kristina, Neven Frketa, Neven Čače, Jelena Roganović, Srđan Banac, Vjekoslav Tomulić and David Gobić. "Successful right atrial thrombus lysis with alteplase in a nine month old infant." Signa vitae : journal for intesive care and emergency medicine 8, no. 1 (2013): 59-61. https://urn.nsk.hr/urn:nbn:hr:184:820255

Lah Tomulić, K., et al. (2013) 'Successful right atrial thrombus lysis with alteplase in a nine month old infant', Signa vitae : journal for intesive care and emergency medicine, 8(1), pp. 59-61. Available at: https://urn.nsk.hr/urn:nbn:hr:184:820255 (Accessed 03 May 2024)

Lah Tomulić K, Frketa N, Čače N, Roganović J, Banac S, Tomulić V, and sur.. Successful right atrial thrombus lysis with alteplase in a nine month old infant. Signa vitae : journal for intesive care and emergency medicine [Internet]. 2013 April 01 [cited 2024 May 03];8(1):59-61. Available at: https://urn.nsk.hr/urn:nbn:hr:184:820255

K. Lah Tomulić, et al., "Successful right atrial thrombus lysis with alteplase in a nine month old infant", Signa vitae : journal for intesive care and emergency medicine, vol. 8, no. 1, pp. 59-61, April 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:820255. [Accessed: 03 May 2024]

Metadata
Title (english)Successful right atrial thrombus lysis with alteplase in a nine month old infant
AuthorKristina Lah Tomulić
AuthorNeven Frketa
AuthorNeven Čače
AuthorJelena Roganović
AuthorSrđan Banac
AuthorVjekoslav Tomulić
AuthorDavid Gobić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Objective. To present the case of an infant with a catheter related atrial thrombus resolved with local instillation of alteplase. Clinical presentation. Echocardiography (ECHO) was performed in an infant with sepsis to estimate cardiac contractility, and a large mobile thrombus (28 x 8 mm) was detected in the right atrium. A left subclavian, double lumen, central venous line (CVL, 4 French, 8 cm), inserted 10 weeks previously, was left in place. Standard treatment with enoxaparine was commenced twice daily for 10 days at a dose of 1 mg/kg. Repeat ECHO showed no changes in thrombus size or mobility. Therefore, alteplase was administered into the distal catheter (1 mg in normal saline) at a dose of 110% of its priming volume. The dwelling time was 2 hours. Since no changes in thrombus size were observed, the same dose was given into the proximal catheter. ECHO performed 24 hours later showed a significant reduction in thrombus size. The third dose of alteplase was administered into the proximal catheter. ECHO showed complete dissolution of the right atrial thrombus. No bleeding was observed during and following therapy, and there were no signs of hemodynamic instability. The CVL was safely removed the same day and no endoluminal thrombus was seen. Conclusion. Local instillation of alteplase in three doses was a safe and effective approach to the management of a large catheter-related intraatrial thrombus. Systemic thrombolytic therapy, associated with an increased risk of bleeding, and open heart surgery were avoided.
Keywords (english)
Languageenglish
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleSigna vitae : journal for intesive care and emergency medicine
Numberingvol. 8, no. 1, pp. 59-61
p-ISSN1334-5605
e-ISSN1845-206X
URN:NBNurn:nbn:hr:184:820255
Publication2013-04-01
Document URLhttp://hrcak.srce.hr/108799
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-19 22:01:59