prikaz prve stranice dokumenta Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome
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Scientific paper - Original scientific paper
Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome
Biochemia medica : Biochemia medica, 22 (2012), 2; 225-236. urn:nbn:hr:184:856636
Čubranić, Zlatko; Madžar, Željko; Matijević, Sanja; Dvornik, Štefica; Fišić, Elizabeta; Tomulić, Vjekoslav; Kunišek, Juraj; Laškarin, Gordana; Kardum, Igor; Zaputović, Luka

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Čubranić, Z., Madžar, Ž., Matijević, S., Dvornik, Š., Fišić, E., Tomulić, V. ... Zaputović, L. (2012). Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome. Biochemia medica : Biochemia medica, 22. (2), 225-236. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:856636

Čubranić, Zlatko, et al. "Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome." Biochemia medica : Biochemia medica, vol. 22, no. 2, 2012, pp. 225-236. https://urn.nsk.hr/urn:nbn:hr:184:856636

Čubranić, Zlatko, Željko Madžar, Sanja Matijević, Štefica Dvornik, Elizabeta Fišić, Vjekoslav Tomulić, Juraj Kunišek, Gordana Laškarin, Igor Kardum and Luka Zaputović. "Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome." Biochemia medica : Biochemia medica 22, no. 2 (2012): 225-236. https://urn.nsk.hr/urn:nbn:hr:184:856636

Čubranić, Z., et al. (2012) 'Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome', Biochemia medica : Biochemia medica, 22(2), pp. 225-236. Available at: https://urn.nsk.hr/urn:nbn:hr:184:856636 (Accessed 19 April 2024)

Čubranić Z, Madžar Ž, Matijević S, Dvornik Š, Fišić E, Tomulić V, and sur.. Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome. Biochemia medica : Biochemia medica [Internet]. 2012 June 15 [cited 2024 April 19];22(2):225-236. Available at: https://urn.nsk.hr/urn:nbn:hr:184:856636

Z. Čubranić, et al., "Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome", Biochemia medica : Biochemia medica, vol. 22, no. 2, pp. 225-236, June 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:856636. [Accessed: 19 April 2024]

Metadata
Title (english)Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome
AuthorZlatko Čubranić
AuthorŽeljko Madžar
AuthorSanja Matijević
AuthorŠtefica Dvornik
AuthorElizabeta Fišić
AuthorVjekoslav Tomulić
AuthorJuraj Kunišek
AuthorGordana Laškarin
AuthorIgor Kardum
AuthorLuka Zaputović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Introduction: This study aimed to assess whether heart fatty acid-binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) could be used for the accurate diagnosis of acute myocardial infarction (AMI) in acute coronary syndrome (ACS) patients. Materials and methods: The study included 108 ACS patients admitted to a coronary unit within 3 h after chest pain onset. AMI was distinguished from unstable angina (UA) using a classical cardiac troponin I (cTnI) assay. H-FABP and GPBB were measured by ELISA on admission (0 h) and at 3, 6, 12, and 24 h after admission; their accuracy to diagnose AMI was assessed using statistical methods. Results: From 92 patients with ACS; 71 had AMI. H-FABP and GPBB had higher peak value after 3 h from admission than cTnI (P = 0.001). Both markers normalized at 24 h. The area under the receiver operating characteristic curves was significantly greater for both markers in AMI patients than in UA patients at all time points tested, including admission (P < 0.001). At admission, the H-FABP (37%) and GPBB (40%) sensitivities were relatively low. They increased at 3 and 6 h after admission for both markers and decreased again after 24 h. It was 40% for H-FABP and approximately 2-times lower for GPBB (P < 0.01). In AMI patients, both biomarkers had similar specificities, positive- and negative-predictive values, positive and negative likelihood ratios, and risk ratios for AIM. Conclusion: H-FABP and GPBB can contribute to early AMI diagnosis and can distinguish AMI from UA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiochemia medica : Biochemia medica
Numberingvol. 22, no. 2, pp. 225-236
p-ISSN1330-0962
URN:NBNurn:nbn:hr:184:856636
Publication2012-06-15
Document URLhttp://hrcak.srce.hr/83227
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-19 22:07:05