prikaz prve stranice dokumenta Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.
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Scientific paper - Original scientific paper
Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.
Scandinavian journal of immunology, 86 (2017), 1; 65-71. https://doi.org/10.1111/sji.12563
Lekić, Andrica; Brekalo, Zdrinko; Kvesić, Ante; Kovačević, Miljenko; Barićev Novaković, Zdenka; Šutić, Ivana; Bulog, Aleksandar; Šutić, Ingrid; Pavišić, Valentino; Mrakovčić-Šutić, Ines

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Lekić, A., Brekalo, Z., Kvesić, A., Kovačević, M., Barićev Novaković, Z., Šutić, I. ... Mrakovčić Šutić, I. (2017). Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.. Scandinavian journal of immunology, 86. (1), 65-71. doi: 10.1111/sji.12563

Lekić, Andrica, et al. "Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.." Scandinavian journal of immunology, vol. 86, no. 1, 2017, pp. 65-71. https://doi.org/10.1111/sji.12563

Lekić, Andrica, Zdrinko Brekalo, Ante Kvesić, Miljenko Kovačević, Zdenka Barićev Novaković, Ivana Šutić, Aleksandar Bulog, Ingrid Šutić, Valentino Pavišić and Ines Mrakovčić Šutić. "Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.." Scandinavian journal of immunology 86, no. 1 (2017): 65-71. https://doi.org/10.1111/sji.12563

Lekić, A., et al. (2017) 'Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.', Scandinavian journal of immunology, 86(1), pp. 65-71. doi: 10.1111/sji.12563

Lekić A, Brekalo Z, Kvesić A, Kovačević M, Barićev Novaković Z, Šutić I, and sur.. Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.. Scandinavian journal of immunology [Internet]. 2017 [cited 2024 November 22];86(1):65-71. doi: 10.1111/sji.12563

A. Lekić, et al., "Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.", Scandinavian journal of immunology, vol. 86, no. 1, pp. 65-71, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:350933. [Accessed: 22 November 2024]

Metadata
Title (english)Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.
AuthorAndrica Lekić
AuthorZdrinko Brekalo
AuthorAnte Kvesić
AuthorMiljenko Kovačević
MBZ: 65695
AuthorZdenka Barićev Novaković
AuthorIvana Šutić
AuthorAleksandar Bulog
AuthorIngrid Šutić
AuthorValentino Pavišić
AuthorInes Mrakovčić-Šutić
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Family Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) in the vascular wall, fatty acids, etc.), and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix metalloproteinases (MMPs), whose concentration are increased in foam cell-rich regions. Regulatory T cells (Tregs) represent a unique subpopulation of T cells specialized in the regulation of immune response and in the suppression of proatherogenic T cells. The aim of our study was to examine the interactions between the concentration of enzyme matrix metalloproteinases 2 and 9 (MMP-2 and 9) in urine and the percentage of Tregs in peripheral blood of two groups of patients: with carotid artery stenosis (CAS), undergoing surgery and with mild atherosclerosis (A) from general practice. The method of enzyme immunoassay (ELISA) was used to determine enzyme MMP expression, and Tregs was examined by flow cytometric analysis. Our data have showed a large increase in the enzyme MMP-2 and 9 in the urine of CAS and A patients in comparison with healthy controls and indicated this method as an easy marker for the monitoring of the development of atherosclerosis. Simultaneously, the diminished number of Tregs in the same patients pointed the importance of these regulatory mechanisms in the etiopathogenesis of atherosclerosis and possible Tregs-mediated therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScandinavian journal of immunology
Numberingvol. 86, no. 1, pp. 65-71
p-ISSN0300-9475
DOIhttps://doi.org/10.1111/sji.12563
URN:NBNurn:nbn:hr:184:350933
Publication2017
ProjectNumber: 13.06.1.1.04
Title (croatian): Endosomalni odjeljci u infekciji mišjim citomegalovirusom
Leader: Pero Lučin
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/884767
Document URLhttp://onlinelibrary.wiley.com/doi/10.1111/sji.12563/abstract
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-10-08 18:32:33