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Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.
Scandinavian journal of immunology, 86 (2017), 1; 65-71. https://doi.org/10.1111/sji.12563
Lekić, Andrica; Brekalo, Zdrinko; Kvesić, Ante; Kovačević, Miljenko; Barićev Novaković, Zdenka; Šutić, Ivana; Bulog, Aleksandar; Šutić, Ingrid; Pavišić, Valentino; Mrakovčić-Šutić, Ines

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Lekić, A., Brekalo, Z., Kvesić, A., Kovačević, M., Barićev Novaković, Z., Šutić, I. ... Mrakovčić Šutić, I. (2017). Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.. Scandinavian journal of immunology, 86. (1), 65-71. doi: 10.1111/sji.12563

Lekić, Andrica, et al. "Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.." Scandinavian journal of immunology, vol. 86, br. 1, 2017, str. 65-71. https://doi.org/10.1111/sji.12563

Lekić, Andrica, Zdrinko Brekalo, Ante Kvesić, Miljenko Kovačević, Zdenka Barićev Novaković, Ivana Šutić, Aleksandar Bulog, Ingrid Šutić, Valentino Pavišić i Ines Mrakovčić Šutić. "Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.." Scandinavian journal of immunology 86, br. 1 (2017): 65-71. https://doi.org/10.1111/sji.12563

Lekić, A., et al. (2017) 'Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.', Scandinavian journal of immunology, 86(1), str. 65-71. doi: 10.1111/sji.12563

Lekić A, Brekalo Z, Kvesić A, Kovačević M, Barićev Novaković Z, Šutić I, i sur.. Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.. Scandinavian journal of immunology [Internet]. 2017. [pristupljeno 22.11.2024.];86(1):65-71. doi: 10.1111/sji.12563

A. Lekić, et al., "Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.", Scandinavian journal of immunology, vol. 86, br. 1, str. 65-71, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:350933. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:350933
Podaci o radu
Naslov (engleski)Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis.
AutorAndrica Lekić
AutorZdrinko Brekalo
AutorAnte Kvesić
AutorMiljenko Kovačević
MBZ: 65695
AutorZdenka Barićev Novaković
AutorIvana Šutić
AutorAleksandar Bulog
AutorIngrid Šutić
AutorValentino Pavišić
AutorInes Mrakovčić-Šutić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Obiteljska medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) in the vascular wall, fatty acids, etc.), and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix metalloproteinases (MMPs), whose concentration are increased in foam cell-rich regions. Regulatory T cells (Tregs) represent a unique subpopulation of T cells specialized in the regulation of immune response and in the suppression of proatherogenic T cells. The aim of our study was to examine the interactions between the concentration of enzyme matrix metalloproteinases 2 and 9 (MMP-2 and 9) in urine and the percentage of Tregs in peripheral blood of two groups of patients: with carotid artery stenosis (CAS), undergoing surgery and with mild atherosclerosis (A) from general practice. The method of enzyme immunoassay (ELISA) was used to determine enzyme MMP expression, and Tregs was examined by flow cytometric analysis. Our data have showed a large increase in the enzyme MMP-2 and 9 in the urine of CAS and A patients in comparison with healthy controls and indicated this method as an easy marker for the monitoring of the development of atherosclerosis. Simultaneously, the diminished number of Tregs in the same patients pointed the importance of these regulatory mechanisms in the etiopathogenesis of atherosclerosis and possible Tregs-mediated therapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScandinavian journal of immunology
Brojčani podacivol. 86, br. 1, str. 65-71
p-ISSN0300-9475
DOIhttps://doi.org/10.1111/sji.12563
URN:NBNurn:nbn:hr:184:350933
Datum objave publikacije2017
ProjektŠifra: 13.06.1.1.04
Naziv (hrvatski): Endosomalni odjeljci u infekciji mišjim citomegalovirusom
Voditelj: Pero Lučin
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://bib.irb.hr/884767
URL dokumentahttp://onlinelibrary.wiley.com/doi/10.1111/sji.12563/abstract
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2017-10-08 18:32:33