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Scientific paper - Original scientific paper
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
Nature, 551 (2017), 7678; 110-114. https://doi.org/10.1038/nature24293
Molgora, Martina; Bonavita, Eduardo; Ponzetta, Andrea; Riva, Federica; Barbagallo, Marialuisa; Jaillon, Sébastien; Popović, Branka; Bernardini, Giovanni; Magrini, Elena; Gianni, Francesca; Zelenay, Santiago; Jonjić, Stipan; Santoni, Angela; Garlanda, Cecilia; Mantovani, Alberto More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Molgora, M., Bonavita, E., Ponzetta, A., Riva, F., Barbagallo, M., Jaillon, S. ... Mantovani, A. (2017). IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature, 551. (7678), 110-114. doi: 10.1038/nature24293

Molgora, Martina, et al. "IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity." Nature, vol. 551, no. 7678, 2017, pp. 110-114. https://doi.org/10.1038/nature24293

Molgora, Martina, Eduardo Bonavita, Andrea Ponzetta, Federica Riva, Marialuisa Barbagallo, Sébastien Jaillon, Branka Popović, et al. "IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity." Nature 551, no. 7678 (2017): 110-114. https://doi.org/10.1038/nature24293

Molgora, M., et al. (2017) 'IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity', Nature, 551(7678), pp. 110-114. doi: 10.1038/nature24293

Molgora M, Bonavita E, Ponzetta A, Riva F, Barbagallo M, Jaillon S, and sur.. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature [Internet]. 2017 November 02 [cited 2024 May 14];551(7678):110-114. doi: 10.1038/nature24293

M. Molgora, et al., "IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity", Nature, vol. 551, no. 7678, pp. 110-114, November 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:608813. [Accessed: 14 May 2024]

Metadata
Title (english)IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
AuthorMartina Molgora
AuthorEduardo Bonavita
AuthorAndrea Ponzetta
AuthorFederica Riva
AuthorMarialuisa Barbagallo
AuthorSébastien Jaillon
AuthorBranka Popović
AuthorGiovanni Bernardini
AuthorElena Magrini
AuthorFrancesca Gianni
AuthorSantiago Zelenay
AuthorStipan Jonjić
AuthorAngela Santoni
AuthorCecilia Garlanda
AuthorAlberto Mantovani
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalling pathways and inflammation(1). Natural killer (NK) cells are innate lymphoid cells which mediate resistance against pathogens and contribute to the activation and orientation of adaptive immune responses(2-4). NK cells mediate resistance against haematopoietic neoplasms but are generally considered to play a minor role in solid tumour carcinogenesis(5-7). Here we report that IL-1R8 serves as a checkpoint for NK cell maturation and effector function. Its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNature
Numberingvol. 551, no. 7678, pp. 110-114
e-ISSN1476-4687
DOIhttps://doi.org/10.1038/nature24293
URN:NBNurn:nbn:hr:184:608813
Publication2017-11-02
ProjectNumber: 669415
Title (english): PTX3 in Humoral Innate Immunity
Acronym: PHII
Jurisdiction: eu
Funding stream: H2020
ProjectNumber: 281608
Title (english): TargetIng novel MEchanisms of Resolution in inflammation
Acronym: TIMER
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: Croatia
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttps://www.nature.com/articles/nature24293
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-12-14 15:20:59