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IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
Nature, 551 (2017), 7678; 110-114. https://doi.org/10.1038/nature24293
Molgora, Martina; Bonavita, Eduardo; Ponzetta, Andrea; Riva, Federica; Barbagallo, Marialuisa; Jaillon, Sébastien; Popović, Branka; Bernardini, Giovanni; Magrini, Elena; Gianni, Francesca; Zelenay, Santiago; Jonjić, Stipan; Santoni, Angela; Garlanda, Cecilia; Mantovani, Alberto Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Molgora, M., Bonavita, E., Ponzetta, A., Riva, F., Barbagallo, M., Jaillon, S. ... Mantovani, A. (2017). IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature, 551. (7678), 110-114. doi: 10.1038/nature24293

Molgora, Martina, et al. "IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity." Nature, vol. 551, br. 7678, 2017, str. 110-114. https://doi.org/10.1038/nature24293

Molgora, Martina, Eduardo Bonavita, Andrea Ponzetta, Federica Riva, Marialuisa Barbagallo, Sébastien Jaillon, Branka Popović, et al. "IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity." Nature 551, br. 7678 (2017): 110-114. https://doi.org/10.1038/nature24293

Molgora, M., et al. (2017) 'IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity', Nature, 551(7678), str. 110-114. doi: 10.1038/nature24293

Molgora M, Bonavita E, Ponzetta A, Riva F, Barbagallo M, Jaillon S, i sur.. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature [Internet]. 02.11.2017. [pristupljeno 07.11.2024.];551(7678):110-114. doi: 10.1038/nature24293

M. Molgora, et al., "IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity", Nature, vol. 551, br. 7678, str. 110-114, Studeni 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:608813. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:608813
Podaci o radu
Naslov (engleski)IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
AutorMartina Molgora
AutorEduardo Bonavita
AutorAndrea Ponzetta
AutorFederica Riva
AutorMarialuisa Barbagallo
AutorSébastien Jaillon
AutorBranka Popović
AutorGiovanni Bernardini
AutorElena Magrini
AutorFrancesca Gianni
AutorSantiago Zelenay
AutorStipan Jonjić
AutorAngela Santoni
AutorCecilia Garlanda
AutorAlberto Mantovani
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalling pathways and inflammation(1). Natural killer (NK) cells are innate lymphoid cells which mediate resistance against pathogens and contribute to the activation and orientation of adaptive immune responses(2-4). NK cells mediate resistance against haematopoietic neoplasms but are generally considered to play a minor role in solid tumour carcinogenesis(5-7). Here we report that IL-1R8 serves as a checkpoint for NK cell maturation and effector function. Its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature
Brojčani podacivol. 551, br. 7678, str. 110-114
e-ISSN1476-4687
DOIhttps://doi.org/10.1038/nature24293
URN:NBNurn:nbn:hr:184:608813
Datum objave publikacije2017-11-02
ProjektŠifra: 669415
Naziv (engleski): PTX3 in Humoral Innate Immunity
Kratica: PHII
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: H2020
ProjektŠifra: 281608
Naziv (engleski): TargetIng novel MEchanisms of Resolution in inflammation
Kratica: TIMER
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttps://www.nature.com/articles/nature24293
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2017-12-14 15:20:59