prikaz prve stranice dokumenta Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice
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Scientific paper - Original scientific paper
Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice
Frontiers in Immunology, 8 (2017); 192. https://doi.org/10.3389/fimmu.2017.00192
Milovanović, Jelena; Popović, Branka; Milovanović, Marija; Kveštak, Daria; Arsenijević, Aleksandar; Stojanović, Bojana; Tanasković, Irena; Krmpotić, Astrid; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag L.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Milovanović, J., Popović, B., Milovanović, M., Kveštak, D., Arsenijević, A., Stojanović, B. ... Lukić, M. L. (2017). Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice. Frontiers in Immunology, 8.. doi: 10.3389/fimmu.2017.00192

Milovanović, Jelena, et al. "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice." Frontiers in Immunology, vol. 8, 2017. https://doi.org/10.3389/fimmu.2017.00192

Milovanović, Jelena, Branka Popović, Marija Milovanović, Daria Kveštak, Aleksandar Arsenijević, Bojana Stojanović, Irena Tanasković, et al. "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice." Frontiers in Immunology 8 (2017). https://doi.org/10.3389/fimmu.2017.00192

Milovanović, J., et al. (2017) 'Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice', Frontiers in Immunology, 8. doi: 10.3389/fimmu.2017.00192

Milovanović J, Popović B, Milovanović M, Kveštak D, Arsenijević A, Stojanović B, and sur.. Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice. Frontiers in Immunology [Internet]. 2017 February 27 [cited 2024 December 26];8. doi: 10.3389/fimmu.2017.00192

J. Milovanović, et al., "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice", Frontiers in Immunology, vol. 8, February 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:264272. [Accessed: 26 December 2024]

Metadata
Title (english)Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice
AuthorJelena Milovanović
AuthorBranka Popović
AuthorMarija Milovanović
AuthorDaria Kveštak
AuthorAleksandar Arsenijević
AuthorBojana Stojanović
AuthorIrena Tanasković
AuthorAstrid Krmpotić
AuthorNebojša Arsenijević
AuthorStipan Jonjić
AuthorMiodrag L. Lukić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
In contrast to C57BL/6 mice, BALB/c mice are relatively resistant to the induction of experimental autoimmune encephalomyelitis (EAE) after challenge with MOG35–55 peptide. Here, we provide the first evidence that infection with murine cytomegalovirus (MCMV) in adulthood abrogates this resistance. Infected BALB/c mice developed clinical and histological signs similar to those seen in susceptible C57BL/6 mice. In addition to CD4+ cells, large proportion of cells in the infiltrate of diseased BALB/c mice was CD8+, similar with findings in multiple sclerosis. CD8+ cells that responded to ex vivo restimulation with MOG35–55 were not specific for viral epitopes pp89 and m164. MCMV infection favors proinflammatory type of dendritic cells (CD86+CD40+CD11c+) in the peripheral lymph organs, M1 type of microglia in central nervous system, and increases development of Th1/Th17 encephalitogenic cells. This study indicates that MCMV may enhance autoimmune neuropathology and abrogate inherent resistance to EAE in mouse strain by enhancing proinflammatory phenotype of antigen-presenting cells, Th1/Th17, and CD8 response to MOG35–55.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Immunology
Numberingvol. 8, 192
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2017.00192
URN:NBNurn:nbn:hr:184:264272
Publication2017-02-27
Document URLhttps://www.frontiersin.org/articles/10.3389/fimmu.2017.00192/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2018-05-23 05:23:32