prikaz prve stranice dokumenta Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice
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Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice
Frontiers in Immunology, 8 (2017); 192. https://doi.org/10.3389/fimmu.2017.00192
Milovanović, Jelena; Popović, Branka; Milovanović, Marija; Kveštak, Daria; Arsenijević, Aleksandar; Stojanović, Bojana; Tanasković, Irena; Krmpotić, Astrid; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag L.

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Milovanović, J., Popović, B., Milovanović, M., Kveštak, D., Arsenijević, A., Stojanović, B. ... Lukić, M. L. (2017). Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice. Frontiers in Immunology, 8.. doi: 10.3389/fimmu.2017.00192

Milovanović, Jelena, et al. "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice." Frontiers in Immunology, vol. 8, 2017. https://doi.org/10.3389/fimmu.2017.00192

Milovanović, Jelena, Branka Popović, Marija Milovanović, Daria Kveštak, Aleksandar Arsenijević, Bojana Stojanović, Irena Tanasković, et al. "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice." Frontiers in Immunology 8 (2017). https://doi.org/10.3389/fimmu.2017.00192

Milovanović, J., et al. (2017) 'Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice', Frontiers in Immunology, 8. doi: 10.3389/fimmu.2017.00192

Milovanović J, Popović B, Milovanović M, Kveštak D, Arsenijević A, Stojanović B, i sur.. Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice. Frontiers in Immunology [Internet]. 27.02.2017. [pristupljeno 26.11.2024.];8. doi: 10.3389/fimmu.2017.00192

J. Milovanović, et al., "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice", Frontiers in Immunology, vol. 8, Veljača 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:264272. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:264272
Podaci o radu
Naslov (engleski)Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice
AutorJelena Milovanović
AutorBranka Popović
AutorMarija Milovanović
AutorDaria Kveštak
AutorAleksandar Arsenijević
AutorBojana Stojanović
AutorIrena Tanasković
AutorAstrid Krmpotić
AutorNebojša Arsenijević
AutorStipan Jonjić
AutorMiodrag L. Lukić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
In contrast to C57BL/6 mice, BALB/c mice are relatively resistant to the induction of experimental autoimmune encephalomyelitis (EAE) after challenge with MOG35–55 peptide. Here, we provide the first evidence that infection with murine cytomegalovirus (MCMV) in adulthood abrogates this resistance. Infected BALB/c mice developed clinical and histological signs similar to those seen in susceptible C57BL/6 mice. In addition to CD4+ cells, large proportion of cells in the infiltrate of diseased BALB/c mice was CD8+, similar with findings in multiple sclerosis. CD8+ cells that responded to ex vivo restimulation with MOG35–55 were not specific for viral epitopes pp89 and m164. MCMV infection favors proinflammatory type of dendritic cells (CD86+CD40+CD11c+) in the peripheral lymph organs, M1 type of microglia in central nervous system, and increases development of Th1/Th17 encephalitogenic cells. This study indicates that MCMV may enhance autoimmune neuropathology and abrogate inherent resistance to EAE in mouse strain by enhancing proinflammatory phenotype of antigen-presenting cells, Th1/Th17, and CD8 response to MOG35–55.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Immunology
Brojčani podacivol. 8, 192
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2017.00192
URN:NBNurn:nbn:hr:184:264272
Datum objave publikacije2017-02-27
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fimmu.2017.00192/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2018-05-23 05:23:32