prikaz prve stranice dokumenta Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin
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Scientific paper - Review paper
Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin
Clinical and Developmental Immunology, 2012 (2012); 180272. https://doi.org/10.1155/2012/180272
Veljković Vujaklija, Danijela; Sučić, Sonja; Gulić, Tamara; Dominović, Marin; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Veljković Vujaklija, D., Sučić, S., Gulić, T., Dominović, M. & Rukavina, D. (2012). Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin. Clinical and Developmental Immunology, 2012.. doi: 10.1155/2012/180272

Veljković Vujaklija, Danijela, et al. "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin." Clinical and Developmental Immunology, vol. 2012, 2012. https://doi.org/10.1155/2012/180272

Veljković Vujaklija, Danijela, Sonja Sučić, Tamara Gulić, Marin Dominović and Daniel Rukavina. "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin." Clinical and Developmental Immunology 2012 (2012). https://doi.org/10.1155/2012/180272

Veljković Vujaklija, D., et al. (2012) 'Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin', Clinical and Developmental Immunology, 2012. doi: 10.1155/2012/180272

Veljković Vujaklija D, Sučić S, Gulić T, Dominović M, Rukavina D. Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin. Clinical and Developmental Immunology [Internet]. 2012 [cited 2024 April 19];2012. doi: 10.1155/2012/180272

D. Veljković Vujaklija, S. Sučić, T. Gulić, M. Dominović and D. Rukavina, "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin", Clinical and Developmental Immunology, vol. 2012, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:273439. [Accessed: 19 April 2024]

Metadata
Title (english)Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin
AuthorDanijela Veljković Vujaklija
AuthorSonja Sučić
AuthorTamara Gulić
AuthorMarin Dominović
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin. Granulysin is especially abundant in NK cells which are able to spontaneously secrete high quantities of granulysin. Besides being a potent bactericidal and tumoricidal molecule, granulysin is also found to be a chemoattractant and a proinflammatory molecule. The precise role(s) of granulysin at the maternal-fetal interface has not been elucidated yet. It is possible that it behaves as a double-edged sword simultaneously acting as an immunomodulatory and a host defense molecule protecting both the mother and the fetus from a wide spectrum of pathogens, and on the other hand, in case of an NK cell activation, acting as an effector molecule causing the apoptosis of semiallograft trophoblast cells and consequently leading to various pregnancy disorders or pregnancy loss.
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical and Developmental Immunology
Numberingvol. 2012, 180272
p-ISSN1740-2522
e-ISSN1740-2530
DOIhttps://doi.org/10.1155/2012/180272
URN:NBNurn:nbn:hr:184:273439
Publication2012
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-07-31 07:02:06