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Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin
Clinical and Developmental Immunology, 2012 (2012); 180272. https://doi.org/10.1155/2012/180272
Veljković Vujaklija, Danijela; Sučić, Sonja; Gulić, Tamara; Dominović, Marin; Rukavina, Daniel

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Veljković Vujaklija, D., Sučić, S., Gulić, T., Dominović, M. i Rukavina, D. (2012). Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin. Clinical and Developmental Immunology, 2012.. doi: 10.1155/2012/180272

Veljković Vujaklija, Danijela, et al. "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin." Clinical and Developmental Immunology, vol. 2012, 2012. https://doi.org/10.1155/2012/180272

Veljković Vujaklija, Danijela, Sonja Sučić, Tamara Gulić, Marin Dominović i Daniel Rukavina. "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin." Clinical and Developmental Immunology 2012 (2012). https://doi.org/10.1155/2012/180272

Veljković Vujaklija, D., et al. (2012) 'Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin', Clinical and Developmental Immunology, 2012. doi: 10.1155/2012/180272

Veljković Vujaklija D, Sučić S, Gulić T, Dominović M, Rukavina D. Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin. Clinical and Developmental Immunology [Internet]. 2012. [pristupljeno 25.12.2024.];2012. doi: 10.1155/2012/180272

D. Veljković Vujaklija, S. Sučić, T. Gulić, M. Dominović i D. Rukavina, "Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin", Clinical and Developmental Immunology, vol. 2012, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:273439. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:273439
Podaci o radu
Naslov (engleski)Cell DeathMechanisms at theMaternal-Fetal Interface: Insights into the Role of Granulysin
AutorDanijela Veljković Vujaklija
AutorSonja Sučić
AutorTamara Gulić
AutorMarin Dominović
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin. Granulysin is especially abundant in NK cells which are able to spontaneously secrete high quantities of granulysin. Besides being a potent bactericidal and tumoricidal molecule, granulysin is also found to be a chemoattractant and a proinflammatory molecule. The precise role(s) of granulysin at the maternal-fetal interface has not been elucidated yet. It is possible that it behaves as a double-edged sword simultaneously acting as an immunomodulatory and a host defense molecule protecting both the mother and the fetus from a wide spectrum of pathogens, and on the other hand, in case of an NK cell activation, acting as an effector molecule causing the apoptosis of semiallograft trophoblast cells and consequently leading to various pregnancy disorders or pregnancy loss.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical and Developmental Immunology
Brojčani podacivol. 2012, 180272
p-ISSN1740-2522
e-ISSN1740-2530
DOIhttps://doi.org/10.1155/2012/180272
URN:NBNurn:nbn:hr:184:273439
Datum objave publikacije2012
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-07-31 07:02:06