prikaz prve stranice dokumenta The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
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Scientific paper - Original scientific paper
The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
Journal of Experimental Medicine, 203 (2006), 8; 1843-1850. https://doi.org/10.1084/jem.20060514
Lenac, Tihana; Budt, Matthias; Arapović, Jurica; Hasan, Milena; Zimmermann, Albert; Šimic, Hrvoje; Krmpotić, Astrid; Messerle, Martin; Ruzsics, Zsolt; Koszinowski, Ulrich H.; Hengel, Hartmut; Jonjić, Stipan

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Lenac, T., Budt, M., Arapović, J., Hasan, M., Zimmermann, A., Šimic, H. ... Jonjić, S. (2006). The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. Journal of Experimental Medicine, 203. (8), 1843-1850. doi: 10.1084/jem.20060514

Lenac, Tihana, et al. "The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60." Journal of Experimental Medicine, vol. 203, no. 8, 2006, pp. 1843-1850. https://doi.org/10.1084/jem.20060514

Lenac, Tihana, Matthias Budt, Jurica Arapović, Milena Hasan, Albert Zimmermann, Hrvoje Šimic, Astrid Krmpotić, et al. "The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60." Journal of Experimental Medicine 203, no. 8 (2006): 1843-1850. https://doi.org/10.1084/jem.20060514

Lenac, T., et al. (2006) 'The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60', Journal of Experimental Medicine, 203(8), pp. 1843-1850. doi: 10.1084/jem.20060514

Lenac T, Budt M, Arapović J, Hasan M, Zimmermann A, Šimic H, and sur.. The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. Journal of Experimental Medicine [Internet]. 2006 [cited 2024 November 08];203(8):1843-1850. doi: 10.1084/jem.20060514

T. Lenac, et al., "The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60", Journal of Experimental Medicine, vol. 203, no. 8, pp. 1843-1850, 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:135073. [Accessed: 08 November 2024]

Metadata
Title (english)The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
AuthorTihana Lenac
AuthorMatthias Budt
AuthorJurica Arapović
AuthorMilena Hasan
AuthorAlbert Zimmermann
AuthorHrvoje Šimic
AuthorAstrid Krmpotić
AuthorMartin Messerle
AuthorZsolt Ruzsics
AuthorUlrich H. Koszinowski
AuthorHartmut Hengel
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Members of the alpha- and beta-subfamily of herpesviridae encode glycoproteins that specifically bind to the Fc part of immunoglobulin (Ig)G. Plasma membrane resident herpesviral Fc receptors seem to prevent virus-specific IgG from activating antibody-dependent effector functions. We show that the mouse cytomegalovirus (MCMV) molecule fcr-1 promotes a rapid down-regulation of NKG2D ligands murine UL16-binding protein like transcript (MULT)-1 and H60 from the cell surface. Deletion of the m138/fcr-1 gene from the MCMV genome attenuates viral replication to natural killer (NK) cell response in an NKG2D-dependent manner in vivo. A distinct N-terminal module within the fcr-1 ectodomain in conjunction with the fcr-1 transmembrane domain was required to dispose MULT-1 to degradation in lysosomes. In contrast, down-modulation of H60 required the complete fcr-1 ectodomain, implying independent modes of fcr-1 interaction with the NKG2D ligands. The results establish a novel viral strategy for down-modulating NK cell responses and highlight the impressive diversity of Fc receptor functions.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Experimental Medicine
Numberingvol. 203, no. 8, pp. 1843-1850
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20060514
URN:NBNurn:nbn:hr:184:135073
Publication2006
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118374/pdf/jem2031843.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-10-14 17:38:13