prikaz prve stranice dokumenta The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
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The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
Journal of Experimental Medicine, 203 (2006), 8; 1843-1850. https://doi.org/10.1084/jem.20060514
Lenac, Tihana; Budt, Matthias; Arapović, Jurica; Hasan, Milena; Zimmermann, Albert; Šimic, Hrvoje; Krmpotić, Astrid; Messerle, Martin; Ruzsics, Zsolt; Koszinowski, Ulrich H.; Hengel, Hartmut; Jonjić, Stipan

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Lenac, T., Budt, M., Arapović, J., Hasan, M., Zimmermann, A., Šimic, H. ... Jonjić, S. (2006). The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. Journal of Experimental Medicine, 203. (8), 1843-1850. doi: 10.1084/jem.20060514

Lenac, Tihana, et al. "The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60." Journal of Experimental Medicine, vol. 203, br. 8, 2006, str. 1843-1850. https://doi.org/10.1084/jem.20060514

Lenac, Tihana, Matthias Budt, Jurica Arapović, Milena Hasan, Albert Zimmermann, Hrvoje Šimic, Astrid Krmpotić, et al. "The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60." Journal of Experimental Medicine 203, br. 8 (2006): 1843-1850. https://doi.org/10.1084/jem.20060514

Lenac, T., et al. (2006) 'The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60', Journal of Experimental Medicine, 203(8), str. 1843-1850. doi: 10.1084/jem.20060514

Lenac T, Budt M, Arapović J, Hasan M, Zimmermann A, Šimic H, i sur.. The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. Journal of Experimental Medicine [Internet]. 2006. [pristupljeno 09.11.2024.];203(8):1843-1850. doi: 10.1084/jem.20060514

T. Lenac, et al., "The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60", Journal of Experimental Medicine, vol. 203, br. 8, str. 1843-1850, 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:135073. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:135073
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Naslov (engleski)The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
AutorTihana Lenac
AutorMatthias Budt
AutorJurica Arapović
AutorMilena Hasan
AutorAlbert Zimmermann
AutorHrvoje Šimic
AutorAstrid Krmpotić
AutorMartin Messerle
AutorZsolt Ruzsics
AutorUlrich H. Koszinowski
AutorHartmut Hengel
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Members of the alpha- and beta-subfamily of herpesviridae encode glycoproteins that specifically bind to the Fc part of immunoglobulin (Ig)G. Plasma membrane resident herpesviral Fc receptors seem to prevent virus-specific IgG from activating antibody-dependent effector functions. We show that the mouse cytomegalovirus (MCMV) molecule fcr-1 promotes a rapid down-regulation of NKG2D ligands murine UL16-binding protein like transcript (MULT)-1 and H60 from the cell surface. Deletion of the m138/fcr-1 gene from the MCMV genome attenuates viral replication to natural killer (NK) cell response in an NKG2D-dependent manner in vivo. A distinct N-terminal module within the fcr-1 ectodomain in conjunction with the fcr-1 transmembrane domain was required to dispose MULT-1 to degradation in lysosomes. In contrast, down-modulation of H60 required the complete fcr-1 ectodomain, implying independent modes of fcr-1 interaction with the NKG2D ligands. The results establish a novel viral strategy for down-modulating NK cell responses and highlight the impressive diversity of Fc receptor functions.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Experimental Medicine
Brojčani podacivol. 203, br. 8, str. 1843-1850
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20060514
URN:NBNurn:nbn:hr:184:135073
Datum objave publikacije2006
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118374/pdf/jem2031843.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-10-14 17:38:13