prikaz prve stranice dokumenta Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population
  Download
PDF 92.86 KB
Scientific paper - Original scientific paper
Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population
Journal of Orthopaedic Research, 29 (2011), 8; 1137-1144. https://doi.org/10.1002/jor.21378
Jotanović, Zdravko; Etokebe, Godfrey Essien; Mihelić, Radovan; Heiland Kårvatn, Marikken; Mulac-Jeričević, Biserka; Tijanic, Tamara; Balen, Sanja; Šestan, Branko; Dembić, Zlatko

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Jotanović, Z., Etokebe, G. E., Mihelić, R., Heiland Kårvatn, M., Mulac Jeričević, B., Tijanic, T. ... Dembić, Z. (2011). Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population. Journal of Orthopaedic Research, 29. (8), 1137-1144. doi: 10.1002/jor.21378

Jotanović, Zdravko, et al. "Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population." Journal of Orthopaedic Research, vol. 29, no. 8, 2011, pp. 1137-1144. https://doi.org/10.1002/jor.21378

Jotanović, Zdravko, Godfrey Essien Etokebe, Radovan Mihelić, Marikken Heiland Kårvatn, Biserka Mulac Jeričević, Tamara Tijanic, Sanja Balen, Branko Šestan and Zlatko Dembić. "Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population." Journal of Orthopaedic Research 29, no. 8 (2011): 1137-1144. https://doi.org/10.1002/jor.21378

Jotanović, Z., et al. (2011) 'Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population', Journal of Orthopaedic Research, 29(8), pp. 1137-1144. doi: 10.1002/jor.21378

Jotanović Z, Etokebe GE, Mihelić R, Heiland Kårvatn M, Mulac Jeričević B, Tijanic T, and sur.. Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population. Journal of Orthopaedic Research [Internet]. 2011 August [cited 2024 December 25];29(8):1137-1144. doi: 10.1002/jor.21378

Z. Jotanović, et al., "Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population", Journal of Orthopaedic Research, vol. 29, no. 8, pp. 1137-1144, August 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:558597. [Accessed: 25 December 2024]

Metadata
Title (english)Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population
AuthorZdravko Jotanović
AuthorGodfrey Essien Etokebe
AuthorRadovan Mihelić
AuthorMarikken Heiland Kårvatn
AuthorBiserka Mulac-Jeričević
AuthorTamara Tijanic
AuthorSanja Balen
MBZ: 236875
AuthorBranko Šestan
AuthorZlatko Dembić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Orthopedics and Physical Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract (english)
Among the predisposing factors to osteoarthritis (OA), a frequent destructive joint disease, is the complex genetic heritage including the interleukin‐1 family members like the IL1β (IL1B) and the IL1 receptor antagonist (IL1RN) genes. The aim of this study was to investigate allelic and genotypic frequencies of the IL1B gene single nucleotide polymorphism (SNP) at −511(G>A) and the variable number tandem repeat (VNTR) in the IL1RN gene in a Croatian Caucasian population of hip OA (HOA) cases and healthy controls. A total of 259 HOA patients with total hip replacement (THR) and 518 healthy blood donors as controls were genotyped for IL1B gene SNP −511(G>A) and the VNTR in the IL1RN gene associated with HOA. The genotype G/A (1/2) at IL1B was significantly associated with the protection of the HOA (p < 0.036, OR = 0.72, 95% CI = 0.52–0.99). The genotype G/G (1/1) had only a trend towards the susceptibility (p = 0.053, OR = 1.35, 95% CI = 0.98–1.86) to disease. None of the haplotypes IL1B −511(G>A) and IL1RN (VNTR) were found associated with the HOA. The haplotype 1–2 at these loci had only a trend to susceptibility (p = 0.065). Haplotype 1–3 had a significant male bias in diseased. Furthermore, genotype comprising 2–1/2–2 haplotypes was found significantly associated with predisposition to HOA (p = 0.027, OR = 2.23, 95% CI = 1.03–4.88), whereas genotype 1–1/2–2 with protection to disease (p = 0.028, OR = 0.65, 95% CI = 0.43–0.97). Our findings suggest that HOA in Croatian population might have a different genetic risk regarding the IL1 locus than has been reported for other Caucasian populations previously.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Orthopaedic Research
Numberingvol. 29, no. 8, pp. 1137-1144
p-ISSN0736-0266
DOIhttps://doi.org/10.1002/jor.21378
URN:NBNurn:nbn:hr:184:558597
Publication2011-08
Publication2011-02-24
Document URLhttp://doi.wiley.com/10.1002/jor.21378
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-10-17 17:17:05