prikaz prve stranice dokumenta Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population
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Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population
Journal of Orthopaedic Research, 29 (2011), 8; 1137-1144. https://doi.org/10.1002/jor.21378
Jotanović, Zdravko; Etokebe, Godfrey Essien; Mihelić, Radovan; Heiland Kårvatn, Marikken; Mulac-Jeričević, Biserka; Tijanic, Tamara; Balen, Sanja; Šestan, Branko; Dembić, Zlatko

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Jotanović, Z., Etokebe, G. E., Mihelić, R., Heiland Kårvatn, M., Mulac Jeričević, B., Tijanic, T. ... Dembić, Z. (2011). Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population. Journal of Orthopaedic Research, 29. (8), 1137-1144. doi: 10.1002/jor.21378

Jotanović, Zdravko, et al. "Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population." Journal of Orthopaedic Research, vol. 29, br. 8, 2011, str. 1137-1144. https://doi.org/10.1002/jor.21378

Jotanović, Zdravko, Godfrey Essien Etokebe, Radovan Mihelić, Marikken Heiland Kårvatn, Biserka Mulac Jeričević, Tamara Tijanic, Sanja Balen, Branko Šestan i Zlatko Dembić. "Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population." Journal of Orthopaedic Research 29, br. 8 (2011): 1137-1144. https://doi.org/10.1002/jor.21378

Jotanović, Z., et al. (2011) 'Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population', Journal of Orthopaedic Research, 29(8), str. 1137-1144. doi: 10.1002/jor.21378

Jotanović Z, Etokebe GE, Mihelić R, Heiland Kårvatn M, Mulac Jeričević B, Tijanic T, i sur.. Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population. Journal of Orthopaedic Research [Internet]. 08.2011. [pristupljeno 07.11.2024.];29(8):1137-1144. doi: 10.1002/jor.21378

Z. Jotanović, et al., "Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population", Journal of Orthopaedic Research, vol. 29, br. 8, str. 1137-1144, Kolovoz 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:558597. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:558597
Podaci o radu
Naslov (engleski)Hip osteoarthritis susceptibility is associated with IL1B −511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population
AutorZdravko Jotanović
AutorGodfrey Essien Etokebe
AutorRadovan Mihelić
AutorMarikken Heiland Kårvatn
AutorBiserka Mulac-Jeričević
AutorTamara Tijanic
AutorSanja Balen
MBZ: 236875
AutorBranko Šestan
AutorZlatko Dembić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kliničko-laboratorijsku dijagnostiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ortopediju i fizikalnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ortopedija
Sažetak (engleski)
Among the predisposing factors to osteoarthritis (OA), a frequent destructive joint disease, is the complex genetic heritage including the interleukin‐1 family members like the IL1β (IL1B) and the IL1 receptor antagonist (IL1RN) genes. The aim of this study was to investigate allelic and genotypic frequencies of the IL1B gene single nucleotide polymorphism (SNP) at −511(G>A) and the variable number tandem repeat (VNTR) in the IL1RN gene in a Croatian Caucasian population of hip OA (HOA) cases and healthy controls. A total of 259 HOA patients with total hip replacement (THR) and 518 healthy blood donors as controls were genotyped for IL1B gene SNP −511(G>A) and the VNTR in the IL1RN gene associated with HOA. The genotype G/A (1/2) at IL1B was significantly associated with the protection of the HOA (p < 0.036, OR = 0.72, 95% CI = 0.52–0.99). The genotype G/G (1/1) had only a trend towards the susceptibility (p = 0.053, OR = 1.35, 95% CI = 0.98–1.86) to disease. None of the haplotypes IL1B −511(G>A) and IL1RN (VNTR) were found associated with the HOA. The haplotype 1–2 at these loci had only a trend to susceptibility (p = 0.065). Haplotype 1–3 had a significant male bias in diseased. Furthermore, genotype comprising 2–1/2–2 haplotypes was found significantly associated with predisposition to HOA (p = 0.027, OR = 2.23, 95% CI = 1.03–4.88), whereas genotype 1–1/2–2 with protection to disease (p = 0.028, OR = 0.65, 95% CI = 0.43–0.97). Our findings suggest that HOA in Croatian population might have a different genetic risk regarding the IL1 locus than has been reported for other Caucasian populations previously.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Orthopaedic Research
Brojčani podacivol. 29, br. 8, str. 1137-1144
p-ISSN0736-0266
DOIhttps://doi.org/10.1002/jor.21378
URN:NBNurn:nbn:hr:184:558597
Datum objave publikacije2011-08
Datum objave publikacije2011-02-24
URL dokumentahttp://doi.wiley.com/10.1002/jor.21378
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-10-17 17:17:05