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Scientific paper - Original scientific paper
Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes
PLOS ONE, 10 (2015), 2; e0118936. https://doi.org/10.1371/journal.pone.0118936
Yossef, Rami; Gur, Chamutal; Shemesh, Avishai; Guttman, Ofer; Hadad, Uzi; Nedvetzki, Shlomo; Miletić, Antonija; Nalbandyan, Karen; Cerwenka, Adelheid; Jonjić, Stipan; Mandelboim, Ofer; Porgador, Angel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Yossef, R., Gur, C., Shemesh, A., Guttman, O., Hadad, U., Nedvetzki, S. ... Porgador, A. (2015). Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes. PLOS ONE, 10. (2). doi: 10.1371/journal.pone.0118936

Yossef, Rami, et al. "Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes." PLOS ONE, vol. 10, no. 2, 2015. https://doi.org/10.1371/journal.pone.0118936

Yossef, Rami, Chamutal Gur, Avishai Shemesh, Ofer Guttman, Uzi Hadad, Shlomo Nedvetzki, Antonija Miletić, et al. "Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes." PLOS ONE 10, no. 2 (2015). https://doi.org/10.1371/journal.pone.0118936

Yossef, R., et al. (2015) 'Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes', PLOS ONE, 10(2). doi: 10.1371/journal.pone.0118936

Yossef R, Gur C, Shemesh A, Guttman O, Hadad U, Nedvetzki S, and sur.. Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes. PLOS ONE [Internet]. 2015 February 26 [cited 2024 May 14];10(2). doi: 10.1371/journal.pone.0118936

R. Yossef, et al., "Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes", PLOS ONE, vol. 10, no. 2, February 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:468753. [Accessed: 14 May 2024]

Metadata
Title (english)Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes
AuthorRami Yossef
AuthorChamutal Gur
AuthorAvishai Shemesh
AuthorOfer Guttman
AuthorUzi Hadad
AuthorShlomo Nedvetzki
AuthorAntonija Miletić
AuthorKaren Nalbandyan
AuthorAdelheid Cerwenka
AuthorStipan Jonjić
AuthorOfer Mandelboim
AuthorAngel Porgador
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer (NK) cells belong to the innate lymphoid cells. Their cytotoxic activity is regulated by the delicate balance between activating and inhibitory signals. NKp46 is a member of the primary activating receptors of NK cells. We previously reported that the NKp46 receptor is involved in the development of type 1 diabetes (T1D). Subsequently, we hypothesized that blocking this receptor could prevent or hinder disease development. To address this goal, we developed monoclonal antibodies for murine NKp46. One mAb, named NCR1.15, recognizes the mouse homologue protein of NKp46, named Ncr1, and was able to down-regulate the surface expression of NKp46 on primary murine NK cells following antibody injection in vivo. Additionally, NCR1.15 treatments were able to down-regulate cytotoxic activity mediated by NKp46, but not by other NK receptors. To test our primary assumption, we examined T1D development in two models, non-obese diabetic mice and low-dose streptozotocin. Our results show a significantly lower incidence of diabetic mice in the NCR1.15-treated group compared to control groups. This study directly demonstrates the involvement of NKp46 in T1D development and suggests a novel treatment strategy for early insulitis.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLOS ONE
Numberingvol. 10, no. 2, e0118936
e-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0118936
URN:NBNurn:nbn:hr:184:468753
Publication2015-02-26
Document URLhttps://dx.plos.org/10.1371/journal.pone.0118936
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-11-07 18:50:54