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Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes
PLOS ONE, 10 (2015), 2; e0118936. https://doi.org/10.1371/journal.pone.0118936
Yossef, Rami; Gur, Chamutal; Shemesh, Avishai; Guttman, Ofer; Hadad, Uzi; Nedvetzki, Shlomo; Miletić, Antonija; Nalbandyan, Karen; Cerwenka, Adelheid; Jonjić, Stipan; Mandelboim, Ofer; Porgador, Angel

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Yossef, R., Gur, C., Shemesh, A., Guttman, O., Hadad, U., Nedvetzki, S. ... Porgador, A. (2015). Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes. PLOS ONE, 10. (2). doi: 10.1371/journal.pone.0118936

Yossef, Rami, et al. "Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes." PLOS ONE, vol. 10, br. 2, 2015. https://doi.org/10.1371/journal.pone.0118936

Yossef, Rami, Chamutal Gur, Avishai Shemesh, Ofer Guttman, Uzi Hadad, Shlomo Nedvetzki, Antonija Miletić, et al. "Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes." PLOS ONE 10, br. 2 (2015). https://doi.org/10.1371/journal.pone.0118936

Yossef, R., et al. (2015) 'Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes', PLOS ONE, 10(2). doi: 10.1371/journal.pone.0118936

Yossef R, Gur C, Shemesh A, Guttman O, Hadad U, Nedvetzki S, i sur.. Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes. PLOS ONE [Internet]. 26.02.2015. [pristupljeno 07.11.2024.];10(2). doi: 10.1371/journal.pone.0118936

R. Yossef, et al., "Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes", PLOS ONE, vol. 10, br. 2, Veljača 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:468753. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:468753
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Naslov (engleski)Targeting Natural Killer Cell Reactivity by Employing Antibody to NKp46: Implications for Type 1 Diabetes
AutorRami Yossef
AutorChamutal Gur
AutorAvishai Shemesh
AutorOfer Guttman
AutorUzi Hadad
AutorShlomo Nedvetzki
AutorAntonija Miletić
AutorKaren Nalbandyan
AutorAdelheid Cerwenka
AutorStipan Jonjić
AutorOfer Mandelboim
AutorAngel Porgador
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Natural killer (NK) cells belong to the innate lymphoid cells. Their cytotoxic activity is regulated by the delicate balance between activating and inhibitory signals. NKp46 is a member of the primary activating receptors of NK cells. We previously reported that the NKp46 receptor is involved in the development of type 1 diabetes (T1D). Subsequently, we hypothesized that blocking this receptor could prevent or hinder disease development. To address this goal, we developed monoclonal antibodies for murine NKp46. One mAb, named NCR1.15, recognizes the mouse homologue protein of NKp46, named Ncr1, and was able to down-regulate the surface expression of NKp46 on primary murine NK cells following antibody injection in vivo. Additionally, NCR1.15 treatments were able to down-regulate cytotoxic activity mediated by NKp46, but not by other NK receptors. To test our primary assumption, we examined T1D development in two models, non-obese diabetic mice and low-dose streptozotocin. Our results show a significantly lower incidence of diabetic mice in the NCR1.15-treated group compared to control groups. This study directly demonstrates the involvement of NKp46 in T1D development and suggests a novel treatment strategy for early insulitis.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS ONE
Brojčani podacivol. 10, br. 2, e0118936
e-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0118936
URN:NBNurn:nbn:hr:184:468753
Datum objave publikacije2015-02-26
URL dokumentahttps://dx.plos.org/10.1371/journal.pone.0118936
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-11-07 18:50:54