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Scientific paper - Original scientific paper
Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates
European Journal of Clinical Chemistry and Cinical Biochemistry, 33 (1995); 915-918. https://doi.org/10.1515/cclm.1995.33.12.915
Marušić, Ana; Katavić, Vedran; Štimac, Dinko; Kušec, Vesna; Jonjić, Stipan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Marušić, A., Katavić, V., Štimac, D., Kušec, V. & Jonjić, S. (1995). Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates. European Journal of Clinical Chemistry and Cinical Biochemistry, 33., 915-918. doi: 10.1515/cclm.1995.33.12.915

Marušić, Ana, et al. "Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates." European Journal of Clinical Chemistry and Cinical Biochemistry, vol. 33, 1995, pp. 915-918. https://doi.org/10.1515/cclm.1995.33.12.915

Marušić, Ana, Vedran Katavić, Dinko Štimac, Vesna Kušec and Stipan Jonjić. "Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates." European Journal of Clinical Chemistry and Cinical Biochemistry 33 (1995): 915-918. https://doi.org/10.1515/cclm.1995.33.12.915

Marušić, A., et al. (1995) 'Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates', European Journal of Clinical Chemistry and Cinical Biochemistry, 33, pp. 915-918. doi: 10.1515/cclm.1995.33.12.915

Marušić A, Katavić V, Štimac D, Kušec V, Jonjić S. Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates. European Journal of Clinical Chemistry and Cinical Biochemistry [Internet]. 1995 [cited 2024 May 13];33:915-918. doi: 10.1515/cclm.1995.33.12.915

A. Marušić, V. Katavić, D. Štimac, V. Kušec and S. Jonjić, "Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates", European Journal of Clinical Chemistry and Cinical Biochemistry, vol. 33, pp. 915-918, 1995. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:201372. [Accessed: 13 May 2024]

Metadata
Title (english)Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates
AuthorAna Marušić
AuthorVedran Katavić
AuthorDinko Štimac
AuthorVesna Kušec
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Beta2-microglobulin is a constituent of the class I major histocompatibility complex (MHC) molecule and crucial for its normal function in cell recognition.It has also been isolated from bone and shown to regulate bone metabolism and to be altered in various bone diseases.In order to further investigate teh role of the immune system in bone metabolism, we studied basic properties of bone physiology in beta2-microglobulin-deficient mice created by the tehnique of gene knock-out.Ten week-old male offspring homozygous (non-functional class I MHC molecule) or heterozygous (functional class I MHC molecule) for beta2-microglobulin knock-out gene did not differ in the following measures of bone turnover: femur lenght, dry and ash weight and calcium content, serum calcium concentration and alkaline phosphatase activity, total vertebral tissue area, trabecular bone volume, osteid surface, osteoclast surface and mineral apposition rate.These data indicate that the bone turnover in beta2-microglobulin-deficient mice is appropriate for the stage of their skeletal maturation.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Clinical Chemistry and Cinical Biochemistry
Numberingvol. 33, pp. 915-918
p-ISSN0939-4974
DOIhttps://doi.org/10.1515/cclm.1995.33.12.915
URN:NBNurn:nbn:hr:184:201372
Publication1995
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-11-22 21:15:07