prikaz prve stranice dokumenta Dok1 and Dok2 proteins regulate natural killer cell development and function
  Download
PDF 1.9 MB
Scientific paper - Original scientific paper
Dok1 and Dok2 proteins regulate natural killer cell development and function
The EMBO Journal, 33 (2014), 17; 1928-1940. https://doi.org/10.15252/embj.201387404
Celis‐Gutierrez, Javier; Boyron, Marilyn; Walzer, Thierry; Pandolfi, Pier Paolo; Jonjić, Stipan; Olive, Daniel; Dalod, Marc; Vivier, Eric; Nunès, Jacques A

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Celis‐Gutierrez, J., Boyron, M., Walzer, T., Pandolfi, P. P., Jonjić, S., Olive, D. ... Nunès, J. A. (2014). Dok1 and Dok2 proteins regulate natural killer cell development and function. The EMBO Journal, 33. (17), 1928-1940. doi: 10.15252/embj.201387404

Celis‐Gutierrez, Javier, et al. "Dok1 and Dok2 proteins regulate natural killer cell development and function." The EMBO Journal, vol. 33, no. 17, 2014, pp. 1928-1940. https://doi.org/10.15252/embj.201387404

Celis‐Gutierrez, Javier, Marilyn Boyron, Thierry Walzer, Pier Paolo Pandolfi, Stipan Jonjić, Daniel Olive, Marc Dalod, Eric Vivier and Jacques A Nunès. "Dok1 and Dok2 proteins regulate natural killer cell development and function." The EMBO Journal 33, no. 17 (2014): 1928-1940. https://doi.org/10.15252/embj.201387404

Celis‐Gutierrez, J., et al. (2014) 'Dok1 and Dok2 proteins regulate natural killer cell development and function', The EMBO Journal, 33(17), pp. 1928-1940. doi: 10.15252/embj.201387404

Celis‐Gutierrez J, Boyron M, Walzer T, Pandolfi PP, Jonjić S, Olive D, and sur.. Dok1 and Dok2 proteins regulate natural killer cell development and function. The EMBO Journal [Internet]. 2014 September 01 [cited 2024 May 14];33(17):1928-1940. doi: 10.15252/embj.201387404

J. Celis‐Gutierrez, et al., "Dok1 and Dok2 proteins regulate natural killer cell development and function", The EMBO Journal, vol. 33, no. 17, pp. 1928-1940, September 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:225147. [Accessed: 14 May 2024]

Metadata
Title (english)Dok1 and Dok2 proteins regulate natural killer cell development and function
AuthorJavier Celis‐Gutierrez
AuthorMarilyn Boyron
AuthorThierry Walzer
AuthorPier Paolo Pandolfi
AuthorStipan Jonjić
AuthorDaniel Olive
AuthorMarc Dalod
AuthorEric Vivier
AuthorJacques A Nunès
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer (NK) cells are involved in immune responses against tumors and microbes. NK-cell activation is regulated by intrinsic and extrinsic mechanisms that ensure NK tolerance and efficacy. Here, we show that the cytoplasmic signaling molecules Dok1 and Dok2 are tyrosine phosphorylated upon NK-cell activation. Overexpression of Dok proteins in human NK cells reduces cell activation induced by NK-cell-activating receptors. Dok1 and Dok2 gene ablation in mice induces an NK-cell maturation defect and leads to increased IFN-γ production induced by activating receptors. Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of NK-cell-activating receptors in mouse and human.
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleThe EMBO Journal
Numberingvol. 33, no. 17, pp. 1928-1940
p-ISSN0261-4189
e-ISSN1460-2075
DOIhttps://doi.org/10.15252/embj.201387404
URN:NBNurn:nbn:hr:184:225147
Publication2014-09-01
Publication2014-06-24
Document URLhttp://emboj.embopress.org/lookup/doi/10.15252/embj.201387404
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2018-12-13 15:52:54