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Dok1 and Dok2 proteins regulate natural killer cell development and function
The EMBO Journal, 33 (2014), 17; 1928-1940. https://doi.org/10.15252/embj.201387404
Celis‐Gutierrez, Javier; Boyron, Marilyn; Walzer, Thierry; Pandolfi, Pier Paolo; Jonjić, Stipan; Olive, Daniel; Dalod, Marc; Vivier, Eric; Nunès, Jacques A

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Celis‐Gutierrez, J., Boyron, M., Walzer, T., Pandolfi, P. P., Jonjić, S., Olive, D. ... Nunès, J. A. (2014). Dok1 and Dok2 proteins regulate natural killer cell development and function. The EMBO Journal, 33. (17), 1928-1940. doi: 10.15252/embj.201387404

Celis‐Gutierrez, Javier, et al. "Dok1 and Dok2 proteins regulate natural killer cell development and function." The EMBO Journal, vol. 33, br. 17, 2014, str. 1928-1940. https://doi.org/10.15252/embj.201387404

Celis‐Gutierrez, Javier, Marilyn Boyron, Thierry Walzer, Pier Paolo Pandolfi, Stipan Jonjić, Daniel Olive, Marc Dalod, Eric Vivier i Jacques A Nunès. "Dok1 and Dok2 proteins regulate natural killer cell development and function." The EMBO Journal 33, br. 17 (2014): 1928-1940. https://doi.org/10.15252/embj.201387404

Celis‐Gutierrez, J., et al. (2014) 'Dok1 and Dok2 proteins regulate natural killer cell development and function', The EMBO Journal, 33(17), str. 1928-1940. doi: 10.15252/embj.201387404

Celis‐Gutierrez J, Boyron M, Walzer T, Pandolfi PP, Jonjić S, Olive D, i sur.. Dok1 and Dok2 proteins regulate natural killer cell development and function. The EMBO Journal [Internet]. 01.09.2014. [pristupljeno 24.12.2024.];33(17):1928-1940. doi: 10.15252/embj.201387404

J. Celis‐Gutierrez, et al., "Dok1 and Dok2 proteins regulate natural killer cell development and function", The EMBO Journal, vol. 33, br. 17, str. 1928-1940, Rujan 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:225147. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:225147
Podaci o radu
Naslov (engleski)Dok1 and Dok2 proteins regulate natural killer cell development and function
AutorJavier Celis‐Gutierrez
AutorMarilyn Boyron
AutorThierry Walzer
AutorPier Paolo Pandolfi
AutorStipan Jonjić
AutorDaniel Olive
AutorMarc Dalod
AutorEric Vivier
AutorJacques A Nunès
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Natural killer (NK) cells are involved in immune responses against tumors and microbes. NK-cell activation is regulated by intrinsic and extrinsic mechanisms that ensure NK tolerance and efficacy. Here, we show that the cytoplasmic signaling molecules Dok1 and Dok2 are tyrosine phosphorylated upon NK-cell activation. Overexpression of Dok proteins in human NK cells reduces cell activation induced by NK-cell-activating receptors. Dok1 and Dok2 gene ablation in mice induces an NK-cell maturation defect and leads to increased IFN-γ production induced by activating receptors. Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of NK-cell-activating receptors in mouse and human.
Ključne riječi (engleski)
Jezikhrvatski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe EMBO Journal
Brojčani podacivol. 33, br. 17, str. 1928-1940
p-ISSN0261-4189
e-ISSN1460-2075
DOIhttps://doi.org/10.15252/embj.201387404
URN:NBNurn:nbn:hr:184:225147
Datum objave publikacije2014-09-01
Datum objave publikacije2014-06-24
URL dokumentahttp://emboj.embopress.org/lookup/doi/10.15252/embj.201387404
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2018-12-13 15:52:54