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Scientific paper - review paper
Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment
Frontiers in Cell and Developmental Biology, 6 (2018); 165. https://doi.org/10.3389/fcell.2018.00165
Lučin, Pero; Kareluša, Ljerka; Blagojević Zagorac, Gordana; Mahmutefendić Lučin, Hana; Pavišić, Valentino; Jug Vučko, Natalia; Lukanović Jurić, Silvija; Marcelić, Marina; Lisnić, Berislav; Jonjić, Stipan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Lučin, P., Kareluša, Lj., Blagojević Zagorac, G., Mahmutefendić Lučin, H., Pavišić, V., Jug Vučko, N. ... Jonjić, S. (2018). Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment. Frontiers in Cell and Developmental Biology, 6.. doi: 10.3389/fcell.2018.00165

Lučin, Pero, et al. "Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment." Frontiers in Cell and Developmental Biology, vol. 6, 2018. https://doi.org/10.3389/fcell.2018.00165

Lučin, Pero, Ljerka Kareluša, Gordana Blagojević Zagorac, Hana Mahmutefendić Lučin, Valentino Pavišić, Natalia Jug Vučko, Silvija Lukanović Jurić, Marina Marcelić, Berislav Lisnić and Stipan Jonjić. "Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment." Frontiers in Cell and Developmental Biology 6 (2018). https://doi.org/10.3389/fcell.2018.00165

Lučin, P., et al. (2018) 'Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment', Frontiers in Cell and Developmental Biology, 6. doi: 10.3389/fcell.2018.00165

Lučin P, Kareluša Lj, Blagojević Zagorac G, Mahmutefendić Lučin H, Pavišić V, Jug Vučko N, and sur.. Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment. Frontiers in Cell and Developmental Biology [Internet]. 2018 December 04 [cited 2024 May 02];6. doi: 10.3389/fcell.2018.00165

P. Lučin, et al., "Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment", Frontiers in Cell and Developmental Biology, vol. 6, December 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:786393. [Accessed: 02 May 2024]

Metadata
Title (english)Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment
AuthorPero Lučin
AuthorLjerka Kareluša
AuthorGordana Blagojević Zagorac
AuthorHana Mahmutefendić Lučin
AuthorValentino Pavišić
AuthorNatalia Jug Vučko
AuthorSilvija Lukanović Jurić
AuthorMarina Marcelić
AuthorBerislav Lisnić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegaloviruses (CMV) reorganize membranous system of the cell in order to develop a virion assembly compartment (VAC). The development starts in the early (E) phase of infection with the reorganization of the endosomal system and the Golgi and proceeds to the late phase until newly formed virions are assembled and released. The events in the E phase involve reorganization of the endosomal recycling compartment (ERC) in a series of cellular alterations that are mostly unknown. In this minireview, we discuss the effect of murine CMV infection on Rab proteins, master regulators of membrane trafficking pathways, which in the cascades with their GEFs and GAPs organize the flow of membranes through the ERC. Immunofluorescence analyzes of murine CMV infected cells suggest perturbations of Rab cascades that operate at the ERC. Analysis of cellular transcriptome in the course of both murine and human CMV infection demonstrates the alteration in expression of cellular genes whose products are known to build Rab cascades. These alterations, however, cannot explain perturbations of the ERC. Cellular proteome data available for human CMV infected cells suggests the potential role of RabGAP downregulation at the end of the E phase. However, the very early onset of the ERC alterations in the course of MCMV infection indicates that CMVs exploit Rab cascades to reorganize the ERC, which represents the earliest step in the sequential establishment of the cVAC.
Keywords (english)
Languageenglish
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Cell and Developmental Biology
Numberingvol. 6, 165
e-ISSN2296-634X
DOIhttps://doi.org/10.3389/fcell.2018.00165
URN:NBNurn:nbn:hr:184:786393
Publication2018-12-04
ProjectNumber: IP-2014-09-9564
Title (croatian): Karakterizacija preuređivanja endosomalnih membranatijekom rane faze infekcije mišjim citomegalovirusom koje vodi k formiranju kompleksa za stvaranje viriona
Acronym: AsCo
Leader: Pero Lučin
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.frontiersin.org/article/10.3389/fcell.2018.00165/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) icon
Created on2018-12-13 18:24:46