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Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment
Frontiers in Cell and Developmental Biology, 6 (2018); 165. https://doi.org/10.3389/fcell.2018.00165
Lučin, Pero; Kareluša, Ljerka; Blagojević Zagorac, Gordana; Mahmutefendić Lučin, Hana; Pavišić, Valentino; Jug Vučko, Natalia; Lukanović Jurić, Silvija; Marcelić, Marina; Lisnić, Berislav; Jonjić, Stipan

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Lučin, P., Kareluša, Lj., Blagojević Zagorac, G., Mahmutefendić Lučin, H., Pavišić, V., Jug Vučko, N. ... Jonjić, S. (2018). Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment. Frontiers in Cell and Developmental Biology, 6.. doi: 10.3389/fcell.2018.00165

Lučin, Pero, et al. "Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment." Frontiers in Cell and Developmental Biology, vol. 6, 2018. https://doi.org/10.3389/fcell.2018.00165

Lučin, Pero, Ljerka Kareluša, Gordana Blagojević Zagorac, Hana Mahmutefendić Lučin, Valentino Pavišić, Natalia Jug Vučko, Silvija Lukanović Jurić, Marina Marcelić, Berislav Lisnić i Stipan Jonjić. "Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment." Frontiers in Cell and Developmental Biology 6 (2018). https://doi.org/10.3389/fcell.2018.00165

Lučin, P., et al. (2018) 'Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment', Frontiers in Cell and Developmental Biology, 6. doi: 10.3389/fcell.2018.00165

Lučin P, Kareluša Lj, Blagojević Zagorac G, Mahmutefendić Lučin H, Pavišić V, Jug Vučko N, i sur.. Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment. Frontiers in Cell and Developmental Biology [Internet]. 04.12.2018. [pristupljeno 09.05.2024.];6. doi: 10.3389/fcell.2018.00165

P. Lučin, et al., "Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment", Frontiers in Cell and Developmental Biology, vol. 6, Prosinac 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:786393. [Citirano: 09.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:786393
Podaci o radu
Naslov (engleski)Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment
AutorPero Lučin
AutorLjerka Kareluša
AutorGordana Blagojević Zagorac
AutorHana Mahmutefendić Lučin
AutorValentino Pavišić
AutorNatalia Jug Vučko
AutorSilvija Lukanović Jurić
AutorMarina Marcelić
AutorBerislav Lisnić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cytomegaloviruses (CMV) reorganize membranous system of the cell in order to develop a virion assembly compartment (VAC). The development starts in the early (E) phase of infection with the reorganization of the endosomal system and the Golgi and proceeds to the late phase until newly formed virions are assembled and released. The events in the E phase involve reorganization of the endosomal recycling compartment (ERC) in a series of cellular alterations that are mostly unknown. In this minireview, we discuss the effect of murine CMV infection on Rab proteins, master regulators of membrane trafficking pathways, which in the cascades with their GEFs and GAPs organize the flow of membranes through the ERC. Immunofluorescence analyzes of murine CMV infected cells suggest perturbations of Rab cascades that operate at the ERC. Analysis of cellular transcriptome in the course of both murine and human CMV infection demonstrates the alteration in expression of cellular genes whose products are known to build Rab cascades. These alterations, however, cannot explain perturbations of the ERC. Cellular proteome data available for human CMV infected cells suggests the potential role of RabGAP downregulation at the end of the E phase. However, the very early onset of the ERC alterations in the course of MCMV infection indicates that CMVs exploit Rab cascades to reorganize the ERC, which represents the earliest step in the sequential establishment of the cVAC.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Cell and Developmental Biology
Brojčani podacivol. 6, 165
e-ISSN2296-634X
DOIhttps://doi.org/10.3389/fcell.2018.00165
URN:NBNurn:nbn:hr:184:786393
Datum objave publikacije2018-12-04
ProjektŠifra: IP-2014-09-9564
Naziv (hrvatski): Karakterizacija preuređivanja endosomalnih membranatijekom rane faze infekcije mišjim citomegalovirusom koje vodi k formiranju kompleksa za stvaranje viriona
Kratica: AsCo
Voditelj: Pero Lučin
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.frontiersin.org/article/10.3389/fcell.2018.00165/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-SA 4.0)
Datum i vrijeme pohrane2018-12-13 18:24:46