prikaz prve stranice dokumenta Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
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Scientific paper - Original scientific paper
Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
Journal of Biological Chemistry, 282 (2007), 48; 35247-35258. https://doi.org/10.1074/jbc.M706782200
Mans, Janet; Natarajan, Kannan; Balbo, Andrea; Schuck, Peter; Eikel, Daniel; Hess, Sonja; Robinson, Howard; Šimić, Hrvoje; Jonjić, Stipan; Tiemessen, Caroline T.; Margulies, David H.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Mans, J., Natarajan, K., Balbo, A., Schuck, P., Eikel, D., Hess, S. ... Margulies, D. H. (2007). Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153. Journal of Biological Chemistry, 282. (48), 35247-35258. doi: 10.1074/jbc.M706782200

Mans, Janet, et al. "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153." Journal of Biological Chemistry, vol. 282, no. 48, 2007, pp. 35247-35258. https://doi.org/10.1074/jbc.M706782200

Mans, Janet, Kannan Natarajan, Andrea Balbo, Peter Schuck, Daniel Eikel, Sonja Hess, Howard Robinson, et al. "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153." Journal of Biological Chemistry 282, no. 48 (2007): 35247-35258. https://doi.org/10.1074/jbc.M706782200

Mans, J., et al. (2007) 'Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153', Journal of Biological Chemistry, 282(48), pp. 35247-35258. doi: 10.1074/jbc.M706782200

Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, and sur.. Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153. Journal of Biological Chemistry [Internet]. 2007 November 30 [cited 2024 July 17];282(48):35247-35258. doi: 10.1074/jbc.M706782200

J. Mans, et al., "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153", Journal of Biological Chemistry, vol. 282, no. 48, pp. 35247-35258, November 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:518082. [Accessed: 17 July 2024]

Metadata
Title (english)Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
AuthorJanet Mans
AuthorKannan Natarajan
AuthorAndrea Balbo
AuthorPeter Schuck
AuthorDaniel Eikel
AuthorSonja Hess
AuthorHoward Robinson
AuthorHrvoje Šimić
AuthorStipan Jonjić
AuthorCaroline T. Tiemessen
AuthorDavid H. Margulies
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Mouse cytomegalovirus (MCMV), a β-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions. MCMV encodes the m145 family of putative immunoevasins with predicted MHC-I structure. Functions attributed to some family members include downregulation of host MHC-I (m152) and NKG2D ligands (m145, m152, m155) and interaction with inhibitory or activating NK receptors (m157). We present the cellular, biochemical and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require β2m or peptide, and is expressed at the surface of MCMV-infected cells. Its 2.4 Å crystal structure confirms that this compact molecule preserves an MHC-I-like fold and reveals a novel mode of dimerization, confirmed by site-directed mutagenesis, and a distinctive disulfide-stabilized extended amino terminus. The structure provides a useful framework for comparative analysis of the divergent members of the m145 family.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleJournal of Biological Chemistry
Numberingvol. 282, no. 48, pp. 35247-35258
p-ISSN0021-9258
e-ISSN1083-351X
DOIhttps://doi.org/10.1074/jbc.M706782200
URN:NBNurn:nbn:hr:184:518082
Publication2007-11-30
Publication2007-09-26
Document URLhttp://www.jbc.org/lookup/doi/10.1074/jbc.M706782200
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-04-10 06:24:42