prikaz prve stranice dokumenta Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
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Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
Journal of Biological Chemistry, 282 (2007), 48; 35247-35258. https://doi.org/10.1074/jbc.M706782200
Mans, Janet; Natarajan, Kannan; Balbo, Andrea; Schuck, Peter; Eikel, Daniel; Hess, Sonja; Robinson, Howard; Šimić, Hrvoje; Jonjić, Stipan; Tiemessen, Caroline T.; Margulies, David H.

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Mans, J., Natarajan, K., Balbo, A., Schuck, P., Eikel, D., Hess, S. ... Margulies, D. H. (2007). Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153. Journal of Biological Chemistry, 282. (48), 35247-35258. doi: 10.1074/jbc.M706782200

Mans, Janet, et al. "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153." Journal of Biological Chemistry, vol. 282, br. 48, 2007, str. 35247-35258. https://doi.org/10.1074/jbc.M706782200

Mans, Janet, Kannan Natarajan, Andrea Balbo, Peter Schuck, Daniel Eikel, Sonja Hess, Howard Robinson, et al. "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153." Journal of Biological Chemistry 282, br. 48 (2007): 35247-35258. https://doi.org/10.1074/jbc.M706782200

Mans, J., et al. (2007) 'Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153', Journal of Biological Chemistry, 282(48), str. 35247-35258. doi: 10.1074/jbc.M706782200

Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, i sur.. Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153. Journal of Biological Chemistry [Internet]. 30.11.2007. [pristupljeno 23.12.2024.];282(48):35247-35258. doi: 10.1074/jbc.M706782200

J. Mans, et al., "Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153", Journal of Biological Chemistry, vol. 282, br. 48, str. 35247-35258, Studeni 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:518082. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:518082
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Naslov (engleski)Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153
AutorJanet Mans
AutorKannan Natarajan
AutorAndrea Balbo
AutorPeter Schuck
AutorDaniel Eikel
AutorSonja Hess
AutorHoward Robinson
AutorHrvoje Šimić
AutorStipan Jonjić
AutorCaroline T. Tiemessen
AutorDavid H. Margulies
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Mouse cytomegalovirus (MCMV), a β-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions. MCMV encodes the m145 family of putative immunoevasins with predicted MHC-I structure. Functions attributed to some family members include downregulation of host MHC-I (m152) and NKG2D ligands (m145, m152, m155) and interaction with inhibitory or activating NK receptors (m157). We present the cellular, biochemical and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require β2m or peptide, and is expressed at the surface of MCMV-infected cells. Its 2.4 Å crystal structure confirms that this compact molecule preserves an MHC-I-like fold and reveals a novel mode of dimerization, confirmed by site-directed mutagenesis, and a distinctive disulfide-stabilized extended amino terminus. The structure provides a useful framework for comparative analysis of the divergent members of the m145 family.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Biological Chemistry
Brojčani podacivol. 282, br. 48, str. 35247-35258
p-ISSN0021-9258
e-ISSN1083-351X
DOIhttps://doi.org/10.1074/jbc.M706782200
URN:NBNurn:nbn:hr:184:518082
Datum objave publikacije2007-11-30
Datum objave publikacije2007-09-26
URL dokumentahttp://www.jbc.org/lookup/doi/10.1074/jbc.M706782200
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-04-10 06:24:42