prikaz prve stranice dokumenta Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc
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Scientific paper - Original scientific paper
Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc
Mediators of Inflammation, 11 (2002), 2; 129-135. urn:nbn:hr:184:062463
Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka; Šimin, Marija; Muhvić, Damir; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Mrakovčić Šutić, I., Radošević Stašić, B., Šimin, M., Muhvić, D. & Rukavina, D. (2002). Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc. Mediators of Inflammation, 11. (2), 129-135. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:062463

Mrakovčić Šutić, Ines, et al. "Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc." Mediators of Inflammation, vol. 11, no. 2, 2002, pp. 129-135. https://urn.nsk.hr/urn:nbn:hr:184:062463

Mrakovčić Šutić, Ines, Biserka Radošević Stašić, Marija Šimin, Damir Muhvić and Daniel Rukavina. "Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc." Mediators of Inflammation 11, no. 2 (2002): 129-135. https://urn.nsk.hr/urn:nbn:hr:184:062463

Mrakovčić Šutić, I., et al. (2002) 'Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc', Mediators of Inflammation, 11(2), pp. 129-135. Available at: https://urn.nsk.hr/urn:nbn:hr:184:062463 (Accessed 08 November 2024)

Mrakovčić Šutić I, Radošević Stašić B, Šimin M, Muhvić D, Rukavina D. Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc. Mediators of Inflammation [Internet]. 2002 [cited 2024 November 08];11(2):129-135. Available at: https://urn.nsk.hr/urn:nbn:hr:184:062463

I. Mrakovčić Šutić, B. Radošević Stašić, M. Šimin, D. Muhvić and D. Rukavina, "Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc", Mediators of Inflammation, vol. 11, no. 2, pp. 129-135, 2002. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:062463. [Accessed: 08 November 2024]

Metadata
Title (english)Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc
AuthorInes Mrakovčić-Šutić
AuthorBiserka Radošević-Stašić
AuthorMarija Šimin
MBZ: 247675
AuthorDamir Muhvić
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
BACKGROUND: Peptidoglycan monomer (PGM), which was originally prepared by biosynthesis from culture fluids of penicillin-treated Brevibacterium divaricatum, is an mmunostimulator, the activities of which might be improved by addition of zinc (Zn) to the basic molecule. METHODS: To test the possible cytotoxic effects of this new analogue, we analyzed the ability of PGM-Zn and PGM to change the phenotypic profile of hepatic and splenic mononuclear lymphatic cells and to affect the growth of malignant T-cell line YAC-1 and syngeneic thymocytes. RESULTS: Pretreatment of C57BL/6 mice primarily with PGM-Zn over 6 days (10/mg/kg ntraperitoneally) significantly enhanced the proportions of NK1.1high+, CD4-CD8-, CD69+, and CD3intermediate/NK1.1+/IL2R-beta+ (NKT) cells in the liver, and major histocompatibility complex class II+, CD69+, and CD8+ cells in the spleen. Both types of cells were highly cytotoxic against YAC-1 and syngeneic thymocytes, increasing the destruction of YAC-1 by 70% on addition of hepatic cells and by 30% on addition of splenic cells. Destruction of thymocytes increased by 10 and 50%, respectively. CONCLUSION: The results point to PGM-Zn as a potent cytotoxicity-inducing agent, which also generates autoreactive NKT cells.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMediators of Inflammation
Numberingvol. 11, no. 2, pp. 129-135
p-ISSN0962-9351
URN:NBNurn:nbn:hr:184:062463
Publication2002
Document URLhttp://bib.irb.hr/88352
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-04-14 21:16:04