prikaz prve stranice dokumenta Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc
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Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc
Mediators of Inflammation, 11 (2002), 2; 129-135. urn:nbn:hr:184:062463
Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka; Šimin, Marija; Muhvić, Damir; Rukavina, Daniel

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Mrakovčić Šutić, I., Radošević Stašić, B., Šimin, M., Muhvić, D. i Rukavina, D. (2002). Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc. Mediators of Inflammation, 11. (2), 129-135. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:062463

Mrakovčić Šutić, Ines, et al. "Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc." Mediators of Inflammation, vol. 11, br. 2, 2002, str. 129-135. https://urn.nsk.hr/urn:nbn:hr:184:062463

Mrakovčić Šutić, Ines, Biserka Radošević Stašić, Marija Šimin, Damir Muhvić i Daniel Rukavina. "Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc." Mediators of Inflammation 11, br. 2 (2002): 129-135. https://urn.nsk.hr/urn:nbn:hr:184:062463

Mrakovčić Šutić, I., et al. (2002) 'Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc', Mediators of Inflammation, 11(2), str. 129-135. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:062463 (Datum pristupa: 09.11.2024.)

Mrakovčić Šutić I, Radošević Stašić B, Šimin M, Muhvić D, Rukavina D. Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc. Mediators of Inflammation [Internet]. 2002. [pristupljeno 09.11.2024.];11(2):129-135. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:062463

I. Mrakovčić Šutić, B. Radošević Stašić, M. Šimin, D. Muhvić i D. Rukavina, "Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc", Mediators of Inflammation, vol. 11, br. 2, str. 129-135, 2002. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:062463. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:062463
Podaci o radu
Naslov (engleski)Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc
AutorInes Mrakovčić-Šutić
AutorBiserka Radošević-Stašić
AutorMarija Šimin
MBZ: 247675
AutorDamir Muhvić
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
BACKGROUND: Peptidoglycan monomer (PGM), which was originally prepared by biosynthesis from culture fluids of penicillin-treated Brevibacterium divaricatum, is an mmunostimulator, the activities of which might be improved by addition of zinc (Zn) to the basic molecule. METHODS: To test the possible cytotoxic effects of this new analogue, we analyzed the ability of PGM-Zn and PGM to change the phenotypic profile of hepatic and splenic mononuclear lymphatic cells and to affect the growth of malignant T-cell line YAC-1 and syngeneic thymocytes. RESULTS: Pretreatment of C57BL/6 mice primarily with PGM-Zn over 6 days (10/mg/kg ntraperitoneally) significantly enhanced the proportions of NK1.1high+, CD4-CD8-, CD69+, and CD3intermediate/NK1.1+/IL2R-beta+ (NKT) cells in the liver, and major histocompatibility complex class II+, CD69+, and CD8+ cells in the spleen. Both types of cells were highly cytotoxic against YAC-1 and syngeneic thymocytes, increasing the destruction of YAC-1 by 70% on addition of hepatic cells and by 30% on addition of splenic cells. Destruction of thymocytes increased by 10 and 50%, respectively. CONCLUSION: The results point to PGM-Zn as a potent cytotoxicity-inducing agent, which also generates autoreactive NKT cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMediators of Inflammation
Brojčani podacivol. 11, br. 2, str. 129-135
p-ISSN0962-9351
URN:NBNurn:nbn:hr:184:062463
Datum objave publikacije2002
URL dokumentahttp://bib.irb.hr/88352
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-04-14 21:16:04