prikaz prve stranice dokumenta Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.
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Scientific paper - Original scientific paper
Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.
Histology and Histopathology, 30 (2015); 931-943. https://doi.org/10.14670/HH-11-597
Jakovac, Hrvoje; Ćuk, Mira; Trobonjača, Zlatko; Mrakovčić-Šutic, Ines; Radošević-Stašić, Biserka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Jakovac, H., Ćuk, M., Trobonjača, Z., Mrakovčić Šutic, I. & Radošević Stašić, B. (2015). Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.. Histology and Histopathology, 30., 931-943. doi: 10.14670/HH-11-597

Jakovac, Hrvoje, et al. "Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.." Histology and Histopathology, vol. 30, 2015, pp. 931-943. https://doi.org/10.14670/HH-11-597

Jakovac, Hrvoje, Mira Ćuk, Zlatko Trobonjača, Ines Mrakovčić Šutic and Biserka Radošević Stašić. "Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.." Histology and Histopathology 30 (2015): 931-943. https://doi.org/10.14670/HH-11-597

Jakovac, H., et al. (2015) 'Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.', Histology and Histopathology, 30, pp. 931-943. doi: 10.14670/HH-11-597

Jakovac H, Ćuk M, Trobonjača Z, Mrakovčić Šutic I, Radošević Stašić B. Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.. Histology and Histopathology [Internet]. 2015 [cited 2024 November 23];30:931-943. doi: 10.14670/HH-11-597

H. Jakovac, M. Ćuk, Z. Trobonjača, I. Mrakovčić Šutic and B. Radošević Stašić, "Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.", Histology and Histopathology, vol. 30, pp. 931-943, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:385826. [Accessed: 23 November 2024]

Metadata
Title (english)Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.
AuthorHrvoje Jakovac
AuthorMira Ćuk
AuthorZlatko Trobonjača
AuthorInes Mrakovčić-Šutic
AuthorBiserka Radošević-Stašić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Glycoprotein 96 (gp96) is an endoplasmic reticulum (ER)-resident heat shock protein. It controls the folding of nascent membrane-spanning and secretory proteins, participates in stress-induced unfolded protein response (UPR) and in pathways leading to proteolysis of damaged proteins through ER- associated degradation pathways and chaperone- mediated autophagy. In addition, gp96 controls the steroid biosynthesis and Ca2+ homeostasis and participates in insulin-IGF/signaling pathways. Besides, owing to its peptide chaperone capacity and ability to interact with antigen-presenting cells, gp96 has been implicated in priming of innate and adaptive immunity. In an attempt to visualize the intensity of ER-stress in thymus and possible participation of gp96 in generation of auto-reactive T cell clones that were detected in regenerating liver, in this study we investigated the dynamics of gp96 expression in partially hepatectomized (pHx) and sham Hx mice. Simultaneously, we detected the thymic expression of receptors responsible for endocytosis of gp96- chaperoned peptides (CD91) and intracellular activation of ER-stress pathways (TLR2), as well as the expression of TGF-β and the distribution of CD4+CD25+FoxP3+ cells. The data have shown that both pHx and sham Hx induced an accelerated apoptosis and hypoplasia in thymus. Partial Hx induced, however, a higher expression of gp96, the translocation of the CD91, TLR2 and TGF-β immunostaining from medulla to cortex and an appearance of Treg cells. The data show that pHx triggers in thymus the ER stress and UPR response and suggest that gp96 participates in the generation of natural Treg cells, which might be involved in the control of liver regeneration in the periphery.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleHistology and Histopathology
Numberingvol. 30, pp. 931-943
p-ISSN0213-3911
DOIhttps://doi.org/10.14670/HH-11-597
URN:NBNurn:nbn:hr:184:385826
Publication2015
Document URLhttp://bib.irb.hr/809645
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-08 08:40:53