prikaz prve stranice dokumenta Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.
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Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.
Histology and Histopathology, 30 (2015); 931-943. https://doi.org/10.14670/HH-11-597
Jakovac, Hrvoje; Ćuk, Mira; Trobonjača, Zlatko; Mrakovčić-Šutic, Ines; Radošević-Stašić, Biserka

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Jakovac, H., Ćuk, M., Trobonjača, Z., Mrakovčić Šutic, I. i Radošević Stašić, B. (2015). Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.. Histology and Histopathology, 30., 931-943. doi: 10.14670/HH-11-597

Jakovac, Hrvoje, et al. "Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.." Histology and Histopathology, vol. 30, 2015, str. 931-943. https://doi.org/10.14670/HH-11-597

Jakovac, Hrvoje, Mira Ćuk, Zlatko Trobonjača, Ines Mrakovčić Šutic i Biserka Radošević Stašić. "Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.." Histology and Histopathology 30 (2015): 931-943. https://doi.org/10.14670/HH-11-597

Jakovac, H., et al. (2015) 'Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.', Histology and Histopathology, 30, str. 931-943. doi: 10.14670/HH-11-597

Jakovac H, Ćuk M, Trobonjača Z, Mrakovčić Šutic I, Radošević Stašić B. Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.. Histology and Histopathology [Internet]. 2015. [pristupljeno 29.12.2024.];30:931-943. doi: 10.14670/HH-11-597

H. Jakovac, M. Ćuk, Z. Trobonjača, I. Mrakovčić Šutic i B. Radošević Stašić, "Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.", Histology and Histopathology, vol. 30, str. 931-943, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:385826. [Citirano: 29.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:385826
Podaci o radu
Naslov (engleski)Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.
AutorHrvoje Jakovac
AutorMira Ćuk
AutorZlatko Trobonjača
AutorInes Mrakovčić-Šutic
AutorBiserka Radošević-Stašić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Glycoprotein 96 (gp96) is an endoplasmic reticulum (ER)-resident heat shock protein. It controls the folding of nascent membrane-spanning and secretory proteins, participates in stress-induced unfolded protein response (UPR) and in pathways leading to proteolysis of damaged proteins through ER- associated degradation pathways and chaperone- mediated autophagy. In addition, gp96 controls the steroid biosynthesis and Ca2+ homeostasis and participates in insulin-IGF/signaling pathways. Besides, owing to its peptide chaperone capacity and ability to interact with antigen-presenting cells, gp96 has been implicated in priming of innate and adaptive immunity. In an attempt to visualize the intensity of ER-stress in thymus and possible participation of gp96 in generation of auto-reactive T cell clones that were detected in regenerating liver, in this study we investigated the dynamics of gp96 expression in partially hepatectomized (pHx) and sham Hx mice. Simultaneously, we detected the thymic expression of receptors responsible for endocytosis of gp96- chaperoned peptides (CD91) and intracellular activation of ER-stress pathways (TLR2), as well as the expression of TGF-β and the distribution of CD4+CD25+FoxP3+ cells. The data have shown that both pHx and sham Hx induced an accelerated apoptosis and hypoplasia in thymus. Partial Hx induced, however, a higher expression of gp96, the translocation of the CD91, TLR2 and TGF-β immunostaining from medulla to cortex and an appearance of Treg cells. The data show that pHx triggers in thymus the ER stress and UPR response and suggest that gp96 participates in the generation of natural Treg cells, which might be involved in the control of liver regeneration in the periphery.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaHistology and Histopathology
Brojčani podacivol. 30, str. 931-943
p-ISSN0213-3911
DOIhttps://doi.org/10.14670/HH-11-597
URN:NBNurn:nbn:hr:184:385826
Datum objave publikacije2015
URL dokumentahttp://bib.irb.hr/809645
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-08 08:40:53