prikaz prve stranice dokumenta Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer
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Scientific paper - Original scientific paper
Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer
Periodicum biologorum, 116 (2014), 4; 409-415. urn:nbn:hr:184:442624
Mrakovčić-Šutić, Ines; Sotošek-Tokmadžić, Vlatka; Ilić Tomaš, Maja; Sotošek, Stanislav; Tlić, Vera; Šutić, Ivana; Pavišić, Valentino; Petković, Marija

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Mrakovčić Šutić, I., Sotošek Tokmadžić, V., Ilić Tomaš, M., Sotošek, S., Tlić, V., Šutić, I. ... Petković, M. (2014). Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer. Periodicum biologorum, 116. (4), 409-415. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:442624

Mrakovčić Šutić, Ines, et al. "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer." Periodicum biologorum, vol. 116, no. 4, 2014, pp. 409-415. https://urn.nsk.hr/urn:nbn:hr:184:442624

Mrakovčić Šutić, Ines, Vlatka Sotošek Tokmadžić, Maja Ilić Tomaš, Stanislav Sotošek, Vera Tlić, Ivana Šutić, Valentino Pavišić and Marija Petković. "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer." Periodicum biologorum 116, no. 4 (2014): 409-415. https://urn.nsk.hr/urn:nbn:hr:184:442624

Mrakovčić Šutić, I., et al. (2014) 'Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer', Periodicum biologorum, 116(4), pp. 409-415. Available at: https://urn.nsk.hr/urn:nbn:hr:184:442624 (Accessed 03 May 2024)

Mrakovčić Šutić I, Sotošek Tokmadžić V, Ilić Tomaš M, Sotošek S, Tlić V, Šutić I, and sur.. Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer. Periodicum biologorum [Internet]. 2014 [cited 2024 May 03];116(4):409-415. Available at: https://urn.nsk.hr/urn:nbn:hr:184:442624

I. Mrakovčić Šutić, et al., "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer", Periodicum biologorum, vol. 116, no. 4, pp. 409-415, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:442624. [Accessed: 03 May 2024]

Metadata
Title (english)Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer
AuthorInes Mrakovčić-Šutić
AuthorVlatka Sotošek-Tokmadžić
AuthorMaja Ilić Tomaš
AuthorStanislav Sotošek
AuthorVera Tlić
AuthorIvana Šutić
AuthorValentino Pavišić
AuthorMarija Petković
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Abstract (english)
Regulatory T cells (Tregs) and NKT cells are two subpopulations of T lymphocytes that independently regulate innate and adaptive immunity, but there is some evidence for cross-talk between Tregs and NKT cells, which allow a new immunoregulatory networks. Activated NKT cells may modulate quantitatively and qualitatively the function of Tregs through IL-2-dependent mechanisms, while Tregs can suppress the proliferation, cytokine release and cytotoxic activity of NKT cells by cell-contact-dependent mechanisms. Tregs may control tumor expansion at the priming, as well as the effector’s phase of T immune responses. Tumor cells provide antigenic stimulation of T cells and interact with the tumor-infiltrated innate immune cells secreting cytokines that are crucial for T-cell differentiation. In this study we examined the prostate tissue infiltrating lymphocytes of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) by flow cytometric technique (FACSCalibur) for determine the number of T, B, NK, NKT and Tregs and investigate the local regulatory immunosurveillance which allows the tumor’s immuneescape. Our results have shown the statistically significantly elevated number of Tregs in prostatic tissue and slightly diminished percentage of NKT cells in prostate cancer patients in comparison to patients with benign prostatic hyperplasia. Although the exact mechanism is still unknown, increased infiltration of prostate tissue with T regulatory cells seems that stimulate the tumor to secrete factors (chemokines) that attract these cells in the tissue of the prostate where they achieve their anti-tumor effect and thus may contribute the tumor progression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePeriodicum biologorum
Numberingvol. 116, no. 4, pp. 409-415
p-ISSN0031-5362
URN:NBNurn:nbn:hr:184:442624
Publication2014
ProjectNumber: 062-0620096-0094
Title (croatian): Regulacijske T i NKT stanice u kontroli tumorskog rasta, opeklina i autoimunosti
Leader: Ines Mrakovčić-Šutić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/767323
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-04-09 12:55:37