prikaz prve stranice dokumenta Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer
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Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer
Periodicum biologorum, 116 (2014), 4; 409-415. urn:nbn:hr:184:442624
Mrakovčić-Šutić, Ines; Sotošek-Tokmadžić, Vlatka; Ilić Tomaš, Maja; Sotošek, Stanislav; Tlić, Vera; Šutić, Ivana; Pavišić, Valentino; Petković, Marija

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Mrakovčić Šutić, I., Sotošek Tokmadžić, V., Ilić Tomaš, M., Sotošek, S., Tlić, V., Šutić, I. ... Petković, M. (2014). Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer. Periodicum biologorum, 116. (4), 409-415. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:442624

Mrakovčić Šutić, Ines, et al. "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer." Periodicum biologorum, vol. 116, br. 4, 2014, str. 409-415. https://urn.nsk.hr/urn:nbn:hr:184:442624

Mrakovčić Šutić, Ines, Vlatka Sotošek Tokmadžić, Maja Ilić Tomaš, Stanislav Sotošek, Vera Tlić, Ivana Šutić, Valentino Pavišić i Marija Petković. "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer." Periodicum biologorum 116, br. 4 (2014): 409-415. https://urn.nsk.hr/urn:nbn:hr:184:442624

Mrakovčić Šutić, I., et al. (2014) 'Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer', Periodicum biologorum, 116(4), str. 409-415. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:442624 (Datum pristupa: 09.05.2024.)

Mrakovčić Šutić I, Sotošek Tokmadžić V, Ilić Tomaš M, Sotošek S, Tlić V, Šutić I, i sur.. Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer. Periodicum biologorum [Internet]. 2014. [pristupljeno 09.05.2024.];116(4):409-415. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:442624

I. Mrakovčić Šutić, et al., "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer", Periodicum biologorum, vol. 116, br. 4, str. 409-415, 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:442624. [Citirano: 09.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:442624
Podaci o radu
Naslov (engleski)Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer
AutorInes Mrakovčić-Šutić
AutorVlatka Sotošek-Tokmadžić
AutorMaja Ilić Tomaš
AutorStanislav Sotošek
AutorVera Tlić
AutorIvana Šutić
AutorValentino Pavišić
AutorMarija Petković
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Sažetak (engleski)
Regulatory T cells (Tregs) and NKT cells are two subpopulations of T lymphocytes that independently regulate innate and adaptive immunity, but there is some evidence for cross-talk between Tregs and NKT cells, which allow a new immunoregulatory networks. Activated NKT cells may modulate quantitatively and qualitatively the function of Tregs through IL-2-dependent mechanisms, while Tregs can suppress the proliferation, cytokine release and cytotoxic activity of NKT cells by cell-contact-dependent mechanisms. Tregs may control tumor expansion at the priming, as well as the effector’s phase of T immune responses. Tumor cells provide antigenic stimulation of T cells and interact with the tumor-infiltrated innate immune cells secreting cytokines that are crucial for T-cell differentiation. In this study we examined the prostate tissue infiltrating lymphocytes of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) by flow cytometric technique (FACSCalibur) for determine the number of T, B, NK, NKT and Tregs and investigate the local regulatory immunosurveillance which allows the tumor’s immuneescape. Our results have shown the statistically significantly elevated number of Tregs in prostatic tissue and slightly diminished percentage of NKT cells in prostate cancer patients in comparison to patients with benign prostatic hyperplasia. Although the exact mechanism is still unknown, increased infiltration of prostate tissue with T regulatory cells seems that stimulate the tumor to secrete factors (chemokines) that attract these cells in the tissue of the prostate where they achieve their anti-tumor effect and thus may contribute the tumor progression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPeriodicum biologorum
Brojčani podacivol. 116, br. 4, str. 409-415
p-ISSN0031-5362
URN:NBNurn:nbn:hr:184:442624
Datum objave publikacije2014
ProjektŠifra: 062-0620096-0094
Naziv (hrvatski): Regulacijske T i NKT stanice u kontroli tumorskog rasta, opeklina i autoimunosti
Voditelj: Ines Mrakovčić-Šutić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/767323
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-04-09 12:55:37