prikaz prve stranice dokumenta Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells
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Scientific paper - Original scientific paper
Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells
European Journal of Immunology, 47 (2017), 8; 1354-1367. https://doi.org/10.1002/eji.201746964
Tršan, Tihana; Vuković, Kristina; Filipović, Petra; Lesac Brizić, Ana; Lemmermann, Niels A.W.; Schober, K.; Busch, Dirk H.; Britt, William J.; Messerle, Martin; Krmpotić, Astrid; Jonjić, Stipan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Tršan, T., Vuković, K., Filipović, P., Lesac Brizić, A., Lemmermann, N. A., Schober, K. ... Jonjić, S. (2017). Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells. European Journal of Immunology, 47. (8), 1354-1367. doi: 10.1002/eji.201746964

Tršan, Tihana, et al. "Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells." European Journal of Immunology, vol. 47, no. 8, 2017, pp. 1354-1367. https://doi.org/10.1002/eji.201746964

Tršan, Tihana, Kristina Vuković, Petra Filipović, Ana Lesac Brizić, Niels A.W. Lemmermann, K. Schober, Dirk H. Busch, et al. "Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells." European Journal of Immunology 47, no. 8 (2017): 1354-1367. https://doi.org/10.1002/eji.201746964

Tršan, T., et al. (2017) 'Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells', European Journal of Immunology, 47(8), pp. 1354-1367. doi: 10.1002/eji.201746964

Tršan T, Vuković K, Filipović P, Lesac Brizić A, Lemmermann NA, Schober K, and sur.. Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells. European Journal of Immunology [Internet]. 2017 [cited 2024 May 14];47(8):1354-1367. doi: 10.1002/eji.201746964

T. Tršan, et al., "Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells", European Journal of Immunology, vol. 47, no. 8, pp. 1354-1367, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:534090. [Accessed: 14 May 2024]

Metadata
Title (english)Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells
AuthorTihana Tršan
AuthorKristina Vuković
AuthorPetra Filipović
AuthorAna Lesac Brizić
AuthorNiels A.W. Lemmermann
AuthorK. Schober
AuthorDirk H. Busch
AuthorWilliam J. Britt
AuthorMartin Messerle
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
CD8+ T-cell vaccines, which would provide protection against tumors is still considered a great challenge in immunotherapy. Here we show the robust potential of cytomegalovirus (CMV) vector expressing the NKG2D ligand RAE-1γ as CD8+ T cell-based vaccine against malignant tumors. Immunization with the CMV vector expressing RAE- 1γ, delayed tumor growth or even provided complete protection against tumor challenge in both prophylactic and therapeutic settings. Moreover, a potent tumor control in mice vaccinated with this vector can be further enhanced by blocking the immune checkpoints TIGIT and PD-1. CMV vector expressing RAE-1γ potentiated expansion of KLRG1+ CD8+ T cells with enhanced effector properties. This vaccination was even more efficient in neonatal mice, resulting in the expansion and long-term maintenance of epitope-specific CD8+ T cells conferring robust resistance against tumor challenge. Our data show that immunomodulation of CD8+ T-cell responses promoted by herpesvirus expressing a ligand for NKG2D receptor can provide a powerful platform for the prevention and treatment of CD8+ T-cell sensitive tumors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 47, no. 8, pp. 1354-1367
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201746964
URN:NBNurn:nbn:hr:184:534090
Publication2017
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://bib.irb.hr/890627
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2020-04-09 13:33:47