prikaz prve stranice dokumenta Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells
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Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells
European Journal of Immunology, 47 (2017), 8; 1354-1367. https://doi.org/10.1002/eji.201746964
Tršan, Tihana; Vuković, Kristina; Filipović, Petra; Lesac Brizić, Ana; Lemmermann, Niels A.W.; Schober, K.; Busch, Dirk H.; Britt, William J.; Messerle, Martin; Krmpotić, Astrid; Jonjić, Stipan

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Tršan, T., Vuković, K., Filipović, P., Lesac Brizić, A., Lemmermann, N. A., Schober, K. ... Jonjić, S. (2017). Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells. European Journal of Immunology, 47. (8), 1354-1367. doi: 10.1002/eji.201746964

Tršan, Tihana, et al. "Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells." European Journal of Immunology, vol. 47, br. 8, 2017, str. 1354-1367. https://doi.org/10.1002/eji.201746964

Tršan, Tihana, Kristina Vuković, Petra Filipović, Ana Lesac Brizić, Niels A.W. Lemmermann, K. Schober, Dirk H. Busch, et al. "Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells." European Journal of Immunology 47, br. 8 (2017): 1354-1367. https://doi.org/10.1002/eji.201746964

Tršan, T., et al. (2017) 'Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells', European Journal of Immunology, 47(8), str. 1354-1367. doi: 10.1002/eji.201746964

Tršan T, Vuković K, Filipović P, Lesac Brizić A, Lemmermann NA, Schober K, i sur.. Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells. European Journal of Immunology [Internet]. 2017. [pristupljeno 15.05.2024.];47(8):1354-1367. doi: 10.1002/eji.201746964

T. Tršan, et al., "Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells", European Journal of Immunology, vol. 47, br. 8, str. 1354-1367, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:534090. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:534090
Podaci o radu
Naslov (engleski)Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells
AutorTihana Tršan
AutorKristina Vuković
AutorPetra Filipović
AutorAna Lesac Brizić
AutorNiels A.W. Lemmermann
AutorK. Schober
AutorDirk H. Busch
AutorWilliam J. Britt
AutorMartin Messerle
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
CD8+ T-cell vaccines, which would provide protection against tumors is still considered a great challenge in immunotherapy. Here we show the robust potential of cytomegalovirus (CMV) vector expressing the NKG2D ligand RAE-1γ as CD8+ T cell-based vaccine against malignant tumors. Immunization with the CMV vector expressing RAE- 1γ, delayed tumor growth or even provided complete protection against tumor challenge in both prophylactic and therapeutic settings. Moreover, a potent tumor control in mice vaccinated with this vector can be further enhanced by blocking the immune checkpoints TIGIT and PD-1. CMV vector expressing RAE-1γ potentiated expansion of KLRG1+ CD8+ T cells with enhanced effector properties. This vaccination was even more efficient in neonatal mice, resulting in the expansion and long-term maintenance of epitope-specific CD8+ T cells conferring robust resistance against tumor challenge. Our data show that immunomodulation of CD8+ T-cell responses promoted by herpesvirus expressing a ligand for NKG2D receptor can provide a powerful platform for the prevention and treatment of CD8+ T-cell sensitive tumors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 47, br. 8, str. 1354-1367
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201746964
URN:NBNurn:nbn:hr:184:534090
Datum objave publikacije2017
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 322693
Naziv (engleski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttp://bib.irb.hr/890627
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-09 13:33:47