prikaz prve stranice dokumenta Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies
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Scientific paper - Original scientific paper
Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies
mAbs, 8 (2016), 3; 491-500. https://doi.org/10.1080/19420862.2015.1134410
Houston, A; Williams, J; Lenac Roviš, Tihana; Shanley, D; O'Riordan, R; Kiely, P; Ball, M; Barry, O; Kelly, J; Fanning, A; MacSharry, J; Mandelboim, O; Singer, B; Jonjić, Stipan; Moore, T More authors...

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Houston, A., Williams, J., Lenac Roviš, T., Shanley, D., O'Riordan, R., Kiely, P. ... Moore, T. (2016). Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies. mAbs, 8. (3), 491-500. doi: 10.1080/19420862.2015.1134410

Houston, A, et al. "Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies." mAbs, vol. 8, no. 3, 2016, pp. 491-500. https://doi.org/10.1080/19420862.2015.1134410

Houston, A, J Williams, Tihana Lenac Roviš, D Shanley, R O'Riordan, P Kiely, M Ball, et al. "Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies." mAbs 8, no. 3 (2016): 491-500. https://doi.org/10.1080/19420862.2015.1134410

Houston, A., et al. (2016) 'Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies', mAbs, 8(3), pp. 491-500. doi: 10.1080/19420862.2015.1134410

Houston A, Williams J, Lenac Roviš T, Shanley D, O'Riordan R, Kiely P, and sur.. Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies. mAbs [Internet]. 2016 [cited 2024 November 26];8(3):491-500. doi: 10.1080/19420862.2015.1134410

A. Houston, et al., "Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies", mAbs, vol. 8, no. 3, pp. 491-500, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:463633. [Accessed: 26 November 2024]

Metadata
Title (english)Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies
AuthorA Houston
AuthorJ Williams
AuthorTihana Lenac Roviš
AuthorD Shanley
AuthorR O'Riordan
AuthorP Kiely
AuthorM Ball
AuthorO Barry
AuthorJ Kelly
AuthorA Fanning
AuthorJ MacSharry
AuthorO Mandelboim
AuthorB Singer
AuthorStipan Jonjić
AuthorT Moore
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Pregnancy-specific glycoproteins (PSGs) are immunoglobulin superfamily members related to the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family and are encoded by ten genes in the human. They are secreted at high levels by placental syncytiotrophoblast into maternal blood during pregnancy, and are implicated in immunoregulation, thromboregulation, and angiogenesis. To determine whether PSGs are expressed in tumors, we characterized 16 novel monoclonal antibodies to human PSG1 and used two that do not cross-react with CEACAMs to study PSG expression in tumors and in the gastrointestinal (GI) tract using tissue arrays and immunohistochemistry. Staining was frequently observed in primary squamous cell carcinomas and colonic adenocarcinomas and was correlated with the degree of tumor differentiation, being largely absent from metastatic samples. Staining was also observed in normal oesophageal and colonic epithelium. PSG expression in the human and mouse GI tract was confirmed using quantitative RT-PCR. However, mRNA expression was several orders of magnitude lower in the GI tract compared to placenta. Our results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlemAbs
Numberingvol. 8, no. 3, pp. 491-500
p-ISSN1942-0862
DOIhttps://doi.org/10.1080/19420862.2015.1134410
URN:NBNurn:nbn:hr:184:463633
Publication2016
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/806708
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2020-04-19 14:29:03