prikaz prve stranice dokumenta Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies
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Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies
mAbs, 8 (2016), 3; 491-500. https://doi.org/10.1080/19420862.2015.1134410
Houston, A; Williams, J; Lenac Roviš, Tihana; Shanley, D; O'Riordan, R; Kiely, P; Ball, M; Barry, O; Kelly, J; Fanning, A; MacSharry, J; Mandelboim, O; Singer, B; Jonjić, Stipan; Moore, T Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Houston, A., Williams, J., Lenac Roviš, T., Shanley, D., O'Riordan, R., Kiely, P. ... Moore, T. (2016). Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies. mAbs, 8. (3), 491-500. doi: 10.1080/19420862.2015.1134410

Houston, A, et al. "Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies." mAbs, vol. 8, br. 3, 2016, str. 491-500. https://doi.org/10.1080/19420862.2015.1134410

Houston, A, J Williams, Tihana Lenac Roviš, D Shanley, R O'Riordan, P Kiely, M Ball, et al. "Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies." mAbs 8, br. 3 (2016): 491-500. https://doi.org/10.1080/19420862.2015.1134410

Houston, A., et al. (2016) 'Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies', mAbs, 8(3), str. 491-500. doi: 10.1080/19420862.2015.1134410

Houston A, Williams J, Lenac Roviš T, Shanley D, O'Riordan R, Kiely P, i sur.. Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies. mAbs [Internet]. 2016. [pristupljeno 24.12.2024.];8(3):491-500. doi: 10.1080/19420862.2015.1134410

A. Houston, et al., "Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies", mAbs, vol. 8, br. 3, str. 491-500, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:463633. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:463633
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Naslov (engleski)Pregnancy-specific glycoprotein (PSG) expression in normal gastrointestinal tract and in tumours detected with novel monoclonal antibodies
AutorA Houston
AutorJ Williams
AutorTihana Lenac Roviš
AutorD Shanley
AutorR O'Riordan
AutorP Kiely
AutorM Ball
AutorO Barry
AutorJ Kelly
AutorA Fanning
AutorJ MacSharry
AutorO Mandelboim
AutorB Singer
AutorStipan Jonjić
AutorT Moore
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Pregnancy-specific glycoproteins (PSGs) are immunoglobulin superfamily members related to the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family and are encoded by ten genes in the human. They are secreted at high levels by placental syncytiotrophoblast into maternal blood during pregnancy, and are implicated in immunoregulation, thromboregulation, and angiogenesis. To determine whether PSGs are expressed in tumors, we characterized 16 novel monoclonal antibodies to human PSG1 and used two that do not cross-react with CEACAMs to study PSG expression in tumors and in the gastrointestinal (GI) tract using tissue arrays and immunohistochemistry. Staining was frequently observed in primary squamous cell carcinomas and colonic adenocarcinomas and was correlated with the degree of tumor differentiation, being largely absent from metastatic samples. Staining was also observed in normal oesophageal and colonic epithelium. PSG expression in the human and mouse GI tract was confirmed using quantitative RT-PCR. However, mRNA expression was several orders of magnitude lower in the GI tract compared to placenta. Our results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisamAbs
Brojčani podacivol. 8, br. 3, str. 491-500
p-ISSN1942-0862
DOIhttps://doi.org/10.1080/19420862.2015.1134410
URN:NBNurn:nbn:hr:184:463633
Datum objave publikacije2016
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/806708
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-19 14:29:03