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Scientific paper - Original scientific paper
Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation
European Journal of Immunology, 48 (2018), 6; 950-964. https://doi.org/10.1002/eji.201847526
Brizić, Ilija; Šušak, Božo; Arapović, Maja; Huszthy, Peter C.; Hiršl, Lea; Kveštak, Daria; Juranić Lisnić, Vanda; Golemac, Mijo; Pernjak Pugel, Ester; Tomac, Jelena; Oxenius, Annetrte; Britt, William J.; Arapović, Jurica; Krmpotić, Astrid; Jonjić, Stipan More authors...

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Brizić, I., Šušak, B., Arapović, M., Huszthy, P. C., Hiršl, L., Kveštak, D. ... Jonjić, S. (2018). Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation. European Journal of Immunology, 48. (6), 950-964. doi: 10.1002/eji.201847526

Brizić, Ilija, et al. "Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation." European Journal of Immunology, vol. 48, no. 6, 2018, pp. 950-964. https://doi.org/10.1002/eji.201847526

Brizić, Ilija, Božo Šušak, Maja Arapović, Peter C. Huszthy, Lea Hiršl, Daria Kveštak, Vanda Juranić Lisnić, et al. "Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation." European Journal of Immunology 48, no. 6 (2018): 950-964. https://doi.org/10.1002/eji.201847526

Brizić, I., et al. (2018) 'Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation', European Journal of Immunology, 48(6), pp. 950-964. doi: 10.1002/eji.201847526

Brizić I, Šušak B, Arapović M, Huszthy PC, Hiršl L, Kveštak D, and sur.. Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation. European Journal of Immunology [Internet]. 2018 [cited 2024 May 14];48(6):950-964. doi: 10.1002/eji.201847526

I. Brizić, et al., "Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation", European Journal of Immunology, vol. 48, no. 6, pp. 950-964, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:970604. [Accessed: 14 May 2024]

Metadata
Title (english)Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation
AuthorIlija Brizić
AuthorBožo Šušak
AuthorMaja Arapović
AuthorPeter C. Huszthy
AuthorLea Hiršl
AuthorDaria Kveštak
AuthorVanda Juranić Lisnić
AuthorMijo Golemac
AuthorEster Pernjak Pugel
AuthorJelena Tomac
AuthorAnnetrte Oxenius
AuthorWilliam J. Britt
AuthorJurica Arapović
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Congenital HCMV infection is a leading infectious cause of long‐term neurodevelopmental sequelae. Infection of newborn mice with mouse cytomegalovirus (MCMV) intraperitoneally is a well‐established model of congenital human cytomegalovirus infection, which best recapitulates the hematogenous route of virus spread to brain and subsequent pathology. Here, we used this model to investigate the role, dynamics, and phenotype of CD8+ T cells in the brain following infection of newborn mice. We show that CD8+ T cells infiltrate the brain and form a pool of tissue‐resident memory T cells (TRM cells) that persist for lifetime. Adoptively transferred virus‐specific CD8+ T cells provide protection against primary MCMV infection in newborn mice, reduce brain pathology, and remain in the brain as TRM cells. Brain CD8+ TRM cells were long‐ lived, slowly proliferating cells able to respond to local challenge infection. Importantly, brain CD8+ TRM cells controlled latent MCMV and their depletion resulted in virus reactivation and enhanced inflammation in brain.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 48, no. 6, pp. 950-964
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201847526
URN:NBNurn:nbn:hr:184:970604
Publication2018
ProjectNumber: 322693
Title (croatian): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
Document URLhttp://bib.irb.hr/1034906
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2020-04-19 18:36:45