prikaz prve stranice dokumenta Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation
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Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation
European Journal of Immunology, 48 (2018), 6; 950-964. https://doi.org/10.1002/eji.201847526
Brizić, Ilija; Šušak, Božo; Arapović, Maja; Huszthy, Peter C.; Hiršl, Lea; Kveštak, Daria; Juranić Lisnić, Vanda; Golemac, Mijo; Pernjak Pugel, Ester; Tomac, Jelena; Oxenius, Annetrte; Britt, William J.; Arapović, Jurica; Krmpotić, Astrid; Jonjić, Stipan Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Brizić, I., Šušak, B., Arapović, M., Huszthy, P. C., Hiršl, L., Kveštak, D. ... Jonjić, S. (2018). Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation. European Journal of Immunology, 48. (6), 950-964. doi: 10.1002/eji.201847526

Brizić, Ilija, et al. "Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation." European Journal of Immunology, vol. 48, br. 6, 2018, str. 950-964. https://doi.org/10.1002/eji.201847526

Brizić, Ilija, Božo Šušak, Maja Arapović, Peter C. Huszthy, Lea Hiršl, Daria Kveštak, Vanda Juranić Lisnić, et al. "Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation." European Journal of Immunology 48, br. 6 (2018): 950-964. https://doi.org/10.1002/eji.201847526

Brizić, I., et al. (2018) 'Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation', European Journal of Immunology, 48(6), str. 950-964. doi: 10.1002/eji.201847526

Brizić I, Šušak B, Arapović M, Huszthy PC, Hiršl L, Kveštak D, i sur.. Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation. European Journal of Immunology [Internet]. 2018. [pristupljeno 10.11.2024.];48(6):950-964. doi: 10.1002/eji.201847526

I. Brizić, et al., "Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation", European Journal of Immunology, vol. 48, br. 6, str. 950-964, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:970604. [Citirano: 10.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:970604
Podaci o radu
Naslov (engleski)Brain‐resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation
AutorIlija Brizić
AutorBožo Šušak
AutorMaja Arapović
AutorPeter C. Huszthy
AutorLea Hiršl
AutorDaria Kveštak
AutorVanda Juranić Lisnić
AutorMijo Golemac
AutorEster Pernjak Pugel
AutorJelena Tomac
AutorAnnetrte Oxenius
AutorWilliam J. Britt
AutorJurica Arapović
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Congenital HCMV infection is a leading infectious cause of long‐term neurodevelopmental sequelae. Infection of newborn mice with mouse cytomegalovirus (MCMV) intraperitoneally is a well‐established model of congenital human cytomegalovirus infection, which best recapitulates the hematogenous route of virus spread to brain and subsequent pathology. Here, we used this model to investigate the role, dynamics, and phenotype of CD8+ T cells in the brain following infection of newborn mice. We show that CD8+ T cells infiltrate the brain and form a pool of tissue‐resident memory T cells (TRM cells) that persist for lifetime. Adoptively transferred virus‐specific CD8+ T cells provide protection against primary MCMV infection in newborn mice, reduce brain pathology, and remain in the brain as TRM cells. Brain CD8+ TRM cells were long‐ lived, slowly proliferating cells able to respond to local challenge infection. Importantly, brain CD8+ TRM cells controlled latent MCMV and their depletion resulted in virus reactivation and enhanced inflammation in brain.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 48, br. 6, str. 950-964
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201847526
URN:NBNurn:nbn:hr:184:970604
Datum objave publikacije2018
ProjektŠifra: 322693
Naziv (hrvatski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: ERDF
URL dokumentahttp://bib.irb.hr/1034906
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2020-04-19 18:36:45