prikaz prve stranice dokumenta Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
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Scientific paper - Original scientific paper
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
Proceedings of the National Academy of Sciences, 110 (2013), 41; 16550-16555. https://doi.org/10.1073/pnas.1310215110
Trsan, T.; Busche, A.; Abram, M.; Wensveen, F. M.; Lemmermann, N. A.; Arapovic, M.; Babic, M.; Tomic, A.; Golemac, M.; Brinkmann, M. M.; Jager, W.; Oxenius, A.; Polic, B.; Krmpotic, A.; Messerle, M.; Jonjic, S. More authors...

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Trsan, T., Busche, A., Abram, M., Wensveen, F. M., Lemmermann, N. A., Arapovic, M. ... Jonjic, S. (2013). Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 . Proceedings of the National Academy of Sciences, 110. (41), 16550-16555. doi: 10.1073/pnas.1310215110

Trsan, T., et al. "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ." Proceedings of the National Academy of Sciences, vol. 110, no. 41, 2013, pp. 16550-16555. https://doi.org/10.1073/pnas.1310215110

Trsan, T., A. Busche, M. Abram, F. M. Wensveen, N. A. Lemmermann, M. Arapovic, M. Babic, et al. "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ." Proceedings of the National Academy of Sciences 110, no. 41 (2013): 16550-16555. https://doi.org/10.1073/pnas.1310215110

Trsan, T., et al. (2013) 'Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ', Proceedings of the National Academy of Sciences, 110(41), pp. 16550-16555. doi: 10.1073/pnas.1310215110

Trsan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapovic M, and sur.. Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 . Proceedings of the National Academy of Sciences [Internet]. 2013 September 19 [cited 2024 May 14];110(41):16550-16555. doi: 10.1073/pnas.1310215110

T. Trsan, et al., "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ", Proceedings of the National Academy of Sciences, vol. 110, no. 41, pp. 16550-16555, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:078260. [Accessed: 14 May 2024]

Metadata
Title (english)Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
AuthorT. Trsan
AuthorA. Busche
AuthorM. Abram
AuthorF. M. Wensveen
AuthorN. A. Lemmermann
AuthorM. Arapovic
AuthorM. Babic
AuthorA. Tomic
AuthorM. Golemac
AuthorM. M. Brinkmann
AuthorW. Jager
AuthorA. Oxenius
AuthorB. Polic
AuthorA. Krmpotic
AuthorM. Messerle
AuthorS. Jonjic
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically relevant infections and tumors. NKG2D is one of the most important activating NK cell receptors that plays a role in costimulation of CD8 T cells. Here we demonstrate that the expression of CD8 T-cell epitope of Listeria monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-inducible protein 1-gamma (RAE-1γ) dramatically enhanced the effectiveness and longevity of epitope-specific CD8 T-cell response and conferred protection against a subsequent challenge infection with Listeria monocytogenes. Unexpectedly, the attenuated growth in vivo of the CMV vector expressing RAE-1γ and its capacity to enhance specific CD8 T-cell response were preserved even in mice lacking NKG2D, implying additional immune function for RAE-1γ beyond engagement of NKG2D. Thus, vectors expressing RAE-1γ represent a promising approach in the development of CD8 T-cell–based vaccines.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProceedings of the National Academy of Sciences
Numberingvol. 110, no. 41, pp. 16550-16555
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.1310215110
URN:NBNurn:nbn:hr:184:078260
Publication2013-09-19
ProjectNumber: 1R01AI083284-01
Title (english): A novel virus-derived adjuvant
Jurisdiction: United States
Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Document URLhttp://www.pnas.org/cgi/doi/10.1073/pnas.1310215110
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2020-11-24 10:32:35