prikaz prve stranice dokumenta Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
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Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
Proceedings of the National Academy of Sciences, 110 (2013), 41; 16550-16555. https://doi.org/10.1073/pnas.1310215110
Trsan, T.; Busche, A.; Abram, M.; Wensveen, F. M.; Lemmermann, N. A.; Arapovic, M.; Babic, M.; Tomic, A.; Golemac, M.; Brinkmann, M. M.; Jager, W.; Oxenius, A.; Polic, B.; Krmpotic, A.; Messerle, M.; Jonjic, S. Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Trsan, T., Busche, A., Abram, M., Wensveen, F. M., Lemmermann, N. A., Arapovic, M. ... Jonjic, S. (2013). Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 . Proceedings of the National Academy of Sciences, 110. (41), 16550-16555. doi: 10.1073/pnas.1310215110

Trsan, T., et al. "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ." Proceedings of the National Academy of Sciences, vol. 110, br. 41, 2013, str. 16550-16555. https://doi.org/10.1073/pnas.1310215110

Trsan, T., A. Busche, M. Abram, F. M. Wensveen, N. A. Lemmermann, M. Arapovic, M. Babic, et al. "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ." Proceedings of the National Academy of Sciences 110, br. 41 (2013): 16550-16555. https://doi.org/10.1073/pnas.1310215110

Trsan, T., et al. (2013) 'Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ', Proceedings of the National Academy of Sciences, 110(41), str. 16550-16555. doi: 10.1073/pnas.1310215110

Trsan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapovic M, i sur.. Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 . Proceedings of the National Academy of Sciences [Internet]. 19.09.2013. [pristupljeno 14.05.2024.];110(41):16550-16555. doi: 10.1073/pnas.1310215110

T. Trsan, et al., "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ", Proceedings of the National Academy of Sciences, vol. 110, br. 41, str. 16550-16555, Rujan 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:078260. [Citirano: 14.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:078260
Podaci o radu
Naslov (engleski)Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
AutorT. Trsan
AutorA. Busche
AutorM. Abram
AutorF. M. Wensveen
AutorN. A. Lemmermann
AutorM. Arapovic
AutorM. Babic
AutorA. Tomic
AutorM. Golemac
AutorM. M. Brinkmann
AutorW. Jager
AutorA. Oxenius
AutorB. Polic
AutorA. Krmpotic
AutorM. Messerle
AutorS. Jonjic
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically relevant infections and tumors. NKG2D is one of the most important activating NK cell receptors that plays a role in costimulation of CD8 T cells. Here we demonstrate that the expression of CD8 T-cell epitope of Listeria monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-inducible protein 1-gamma (RAE-1γ) dramatically enhanced the effectiveness and longevity of epitope-specific CD8 T-cell response and conferred protection against a subsequent challenge infection with Listeria monocytogenes. Unexpectedly, the attenuated growth in vivo of the CMV vector expressing RAE-1γ and its capacity to enhance specific CD8 T-cell response were preserved even in mice lacking NKG2D, implying additional immune function for RAE-1γ beyond engagement of NKG2D. Thus, vectors expressing RAE-1γ represent a promising approach in the development of CD8 T-cell–based vaccines.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProceedings of the National Academy of Sciences
Brojčani podacivol. 110, br. 41, str. 16550-16555
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.1310215110
URN:NBNurn:nbn:hr:184:078260
Datum objave publikacije2013-09-19
ProjektŠifra: 1R01AI083284-01
Naziv (engleski): A novel virus-derived adjuvant
Pravna nadležnost: Sjedinjene Američke Države
Financijer: NIH
Linija financiranja: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
URL dokumentahttp://www.pnas.org/cgi/doi/10.1073/pnas.1310215110
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-11-24 10:32:35