prikaz prve stranice dokumenta Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats
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Scientific paper - Original scientific paper
Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats
International Journal of Molecular Sciences, 21 (2020), 23; 8981. https://doi.org/10.3390/ijms21238981
Giacometti, Jasminka; Muhvić, Damir; Grubić Kezele, Tanja; Nikolić, Marina; Šoić-Vranić, Tamara; Bajek, Snježana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Giacometti, J., Muhvić, D., Grubić Kezele, T., Nikolić, M., Šoić Vranić, T. & Bajek, S. (2020). Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats. International Journal of Molecular Sciences, 21. (23). doi: 10.3390/ijms21238981

Giacometti, Jasminka, et al. "Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats." International Journal of Molecular Sciences, vol. 21, no. 23, 2020. https://doi.org/10.3390/ijms21238981

Giacometti, Jasminka, Damir Muhvić, Tanja Grubić Kezele, Marina Nikolić, Tamara Šoić Vranić and Snježana Bajek. "Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats." International Journal of Molecular Sciences 21, no. 23 (2020). https://doi.org/10.3390/ijms21238981

Giacometti, J., et al. (2020) 'Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats', International Journal of Molecular Sciences, 21(23). doi: 10.3390/ijms21238981

Giacometti J, Muhvić D, Grubić Kezele T, Nikolić M, Šoić Vranić T, Bajek S. Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats. International Journal of Molecular Sciences [Internet]. 2020 November 26 [cited 2024 May 05];21(23). doi: 10.3390/ijms21238981

J. Giacometti, D. Muhvić, T. Grubić Kezele, M. Nikolić, T. Šoić Vranić and S. Bajek, "Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats", International Journal of Molecular Sciences, vol. 21, no. 23, November 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:881700. [Accessed: 05 May 2024]

Metadata
Title (english)Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats
AuthorJasminka Giacometti
AuthorDamir Muhvić
AuthorTanja Grubić Kezele
AuthorMarina Nikolić
AuthorTamara Šoić-Vranić
AuthorSnježana Bajek
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract (english)
Skeletal muscles are high-insulin tissues responsible for disposing of glucose via the highly regulated process of facilitated glucose transporter 4 (GLUT4). Impaired insulin action in diabetes, as well as disorders of GLUT4 vesicle trafficking in the muscle, are involved in defects in insulin-stimulated GLUT4 translocation. Since the Rab GTPases are the main regulators of vesicular membrane transport in exo- and endo-cytosis, in the present work, we studied the effect of olive leaf polyphenols (OLPs) on Rab8A, Rab13, and Rab14 proteins of the rat soleus muscle in a model of streptozotocin (SZT)-induced diabetes (DM) in a dose-dependent manner. Glucose, cholesterol, and triglyceride levels were determined in the blood, morphological changes of the muscle tissue were captured by hematoxylin and eosin histological staining, and expression of GLUT4, Rab8A, Rab13, and Rab14 proteins were analyzed in the rat soleus muscle by the immunofluorescence staining and immunoblotting. OLPs significantly reduced blood glucose level in all treated groups. Furthermore, significantly reduced blood triglycerides were found in the groups with the lowest and highest OLPs treatment. The dynamics of activation of Rab8A, Rab13, and Rab14 was OLPs dose-dependent and more effective at higher OLP doses. Thus, these results indicate a beneficial role of phenolic compounds from the olive leaf in the regulation of glucose homeostasis in the skeletal muscle.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 21, no. 23, 8981
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms21238981
URN:NBNurn:nbn:hr:184:881700
Publication2020-11-26
Document URLhttps://www.mdpi.com/1422-0067/21/23/8981
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-12-15 12:46:54