prikaz prve stranice dokumenta Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats
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Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats
International Journal of Molecular Sciences, 21 (2020), 23; 8981. https://doi.org/10.3390/ijms21238981
Giacometti, Jasminka; Muhvić, Damir; Grubić Kezele, Tanja; Nikolić, Marina; Šoić-Vranić, Tamara; Bajek, Snježana

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Giacometti, J., Muhvić, D., Grubić Kezele, T., Nikolić, M., Šoić Vranić, T. i Bajek, S. (2020). Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats. International Journal of Molecular Sciences, 21. (23). doi: 10.3390/ijms21238981

Giacometti, Jasminka, et al. "Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats." International Journal of Molecular Sciences, vol. 21, br. 23, 2020. https://doi.org/10.3390/ijms21238981

Giacometti, Jasminka, Damir Muhvić, Tanja Grubić Kezele, Marina Nikolić, Tamara Šoić Vranić i Snježana Bajek. "Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats." International Journal of Molecular Sciences 21, br. 23 (2020). https://doi.org/10.3390/ijms21238981

Giacometti, J., et al. (2020) 'Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats', International Journal of Molecular Sciences, 21(23). doi: 10.3390/ijms21238981

Giacometti J, Muhvić D, Grubić Kezele T, Nikolić M, Šoić Vranić T, Bajek S. Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats. International Journal of Molecular Sciences [Internet]. 26.11.2020. [pristupljeno 18.05.2024.];21(23). doi: 10.3390/ijms21238981

J. Giacometti, D. Muhvić, T. Grubić Kezele, M. Nikolić, T. Šoić Vranić i S. Bajek, "Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats", International Journal of Molecular Sciences, vol. 21, br. 23, Studeni 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:881700. [Citirano: 18.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:881700
Podaci o radu
Naslov (engleski)Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats
AutorJasminka Giacometti
AutorDamir Muhvić
AutorTanja Grubić Kezele
AutorMarina Nikolić
AutorTamara Šoić-Vranić
AutorSnježana Bajek
Autorova ustanovaSveučilište u Rijeci
(Fakultet biotehnologije i razvoja lijekova)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Sažetak (engleski)
Skeletal muscles are high-insulin tissues responsible for disposing of glucose via the highly regulated process of facilitated glucose transporter 4 (GLUT4). Impaired insulin action in diabetes, as well as disorders of GLUT4 vesicle trafficking in the muscle, are involved in defects in insulin-stimulated GLUT4 translocation. Since the Rab GTPases are the main regulators of vesicular membrane transport in exo- and endo-cytosis, in the present work, we studied the effect of olive leaf polyphenols (OLPs) on Rab8A, Rab13, and Rab14 proteins of the rat soleus muscle in a model of streptozotocin (SZT)-induced diabetes (DM) in a dose-dependent manner. Glucose, cholesterol, and triglyceride levels were determined in the blood, morphological changes of the muscle tissue were captured by hematoxylin and eosin histological staining, and expression of GLUT4, Rab8A, Rab13, and Rab14 proteins were analyzed in the rat soleus muscle by the immunofluorescence staining and immunoblotting. OLPs significantly reduced blood glucose level in all treated groups. Furthermore, significantly reduced blood triglycerides were found in the groups with the lowest and highest OLPs treatment. The dynamics of activation of Rab8A, Rab13, and Rab14 was OLPs dose-dependent and more effective at higher OLP doses. Thus, these results indicate a beneficial role of phenolic compounds from the olive leaf in the regulation of glucose homeostasis in the skeletal muscle.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 21, br. 23, 8981
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms21238981
URN:NBNurn:nbn:hr:184:881700
Datum objave publikacije2020-11-26
URL dokumentahttps://www.mdpi.com/1422-0067/21/23/8981
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-12-15 12:46:54